A Case of Propylthiouracil Induced Diffuse Pulmonary Hemorrhage.

Lee, Sung Yong; Jung, Jin Yong; Lee, Kyoung Ju; Lee, Seung Hyeun; Kim, Se Joong; Lee, Eun Joo; Hur, Gyu Young; Jung, Hae Chul; Lee, Sang Yeub; Kim, Je Hyeong; Shin, Chol; Shim, Jae Jeong; In, Kwang Ho; Kang, Kyung Ho; Yoo, Se Hwa

doi:2005.58.1.78

Tuberc Respir Dis > Volume 58(1); 2005 > Article

Case Report

Tuberculosis and Respiratory Diseases 2005;58(1):78-82.
DOI: https://doi.org/10.4046/trd.2005.58.1.78 Published online January 1, 2005.

A Case of Propylthiouracil Induced Diffuse Pulmonary Hemorrhage.

Sung Yong Lee, Jin Yong Jung, Kyoung Ju Lee, Seung Hyeun Lee, Se Joong Kim, Eun Joo Lee, Gyu Young Hur, Hae Chul Jung, Sang Yeub Lee, Je Hyeong Kim, Chol Shin, Jae Jeong Shim, Kwang Ho In, Kyung Ho Kang, Se Hwa Yoo

Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea. jaejshim@kumc.or.kr

Abstract

Propylthiouracil(PUT) is a drug which used at Grave's disease. But PTU has recently been observed to associated with antineutrophil cytoplasmic antibody(ANCA)-positive vasculitis resulting in, infrequently, diffuse alveolar he?morrhage. We report the case of a patient who developed diffuse pulmonary hemorrhage after she had been taking PTU for two years. She had received a diagnosis of Grave's disease at two years ago. The serologic study was positive for ANCA with myeloperoxidase(MPO) specificity. Bronchoalveloar lavage(BAL) fluid analysis revealed hemosiderin- laden macrophages. Such findings suggested propylthiouracil?induced dffuse pulmonary hemorrhage associated with antineutrophil cytoplasmic antibody. To our knowledge, this represents the first documentation in a case of PTU-induced diffuse pulmonary hemorrhage in Korea.

Key Words: Propylthiouracil, ANCA, Diffuse alveolar hemorrhage