| Study of Serum Alpha1 Antitrypsin Levels and Protease Inhibitor System in Korean Patients with Chronic Obstructive Pulmonary diseases |
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Youn Suck Koh1, Ho Ju Yun1, Woo Jin Lew1, Sung Soo Park1, Jung Hee Lee1, Youl Hey Cho2 |
1Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea
2Department of Genetics, College of Medicine, Hanyang University, Seoul, Korea |
| 한국인 만성폐쇄성 호흡기질환 환자들에 있어서 혈중 Alpha1-Antitrypsin치와 Protease Inhibitor 표현형에 관한 연구 |
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고윤석1, 윤호주1, 류우진1, 박성수1, 이정희1, 조율희2 |
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| Abstract |
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In Korea, Pi phenotype of severe α1-antitrypsin deficiency has been to be rare, but it has not been perforrned the study on Pi phenotype in patients with chronic obstructive pulmonary disease. The serum α1-antitrypsin levels, the Pi phenotype, and subtype of PiM have studied in 45 patients with chronic obstructive pulmonary disease, 57 patients with other lung diseases, and 364 normal persons.
The results were as follows:
1) The mean values of α1-antitrypsin level was 262 ± 97 mg/ dL in chronic obstructive pulmonary disease, 263 ± 97 mg/ dL in other lung diseases, and 198 ± 30 mg/ dL in healthy control. There are statistical differences of α1-antitrypsin level between chronic obstructive pulmonary disease and healthy control with significance (P < 0.05).
2) Forty four cases were subtype of PiM among 45 patients with chronic obstructive pulmonary disease patients and another 1 cases was PiM1 Z. All patients with other lung disease were PiM subtype.
3) The prevalence of PiM subtype were M1M1 59.1%, M2M2 2.3%, M3M3 0%, M1M2 15.9%, M2M3 9.1 %, and M1M3 13.6% in patients with chronic obstructive pulmonary disease. There was no significant statistical difference in the prevalence of PiM subtype, comparing to PiM subtypes of other lung disease and healthy control (p> 0.05).
4) Allele frequencies of Pi system were estimated to be M1 0.7333, M2 0.1444, M3 0.1111, and Z 0.0111 in patients with chronic pulmonary disease. The results of X2-test for deviation from Hardy-Weinberg equilibrium was no statistical difference with significance (p>0.05). |
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