Cefotiam Concentrations in Bronchial Secretions |
W. S. Kim1, H. S. Chung1, Y. W. Kim1, S. K. Han1, Y. S. Shim1, K. Y. Kim1, Y. C. Han1, B. M. Shin2, E. C. Kim2 |
1Department of Internal Medicine and Tuberculosis Research lnstitute, College of Medicine, Seoul National University, Seoul, Korea 2Department of Clinical Pathology, College of Medicine, Seoul National University, Seoul, Korea |
기관지감염 환자에서의 기관지분비물내 Cefotiam 농도 |
김우성1, 정희순1, 김영환1, 한성구1, 심영수1, 김건열1, 한용철1, 신보문2, 김의종2 |
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Abstract |
The penetration of cefotiam into bronchial secretions was evaluated in 20 patients with acute bacterial infections after administration of a single intravenous dose of cefotiam 1 g. Bronchial secretions were aspirated bronchoscopically, in 1, 2, 3 & 4 hours after cefotiam infusion and serum was sampled simultaneously. Cefotiam concentrations were measured by thin layer cup methods.
Cefotiam concentrations in bronchial secretions were 2.2, 2.5, 2.2, 3.3 mcg/ ml at 1, 2, 3 and 4 hours, respectively, which were higher than minimum inhibitory concentrations for E . coli, K. pneumonia, H. influenza & P. mirabilis. The ratios of the cefotiam concentration in the bronchial secretion to that in the serum at the same tirne were 0.70 and 1.27 in 3 & 4 hours. The results confirm the rapid and significant diffusion of cefotiam into the bronchial secretion, especially in the presence of acute bacterial infection. |
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