Acute Respiratory Distress Syndrome after Topotecan Therapy in a Patient with Small Cell Lung Cancer. |
Jung Hyun Tae, Jin Hwa Lee, Yoon Kyung Kim, Yun Su Sim, Kyung Jong Lee, Young Wook Noh, Jae Jung Park, Yon Ju Ryu, Eun Mi Chun, Jung Hyun Chang |
1Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea. jinhwalee@ewha.ac.kr 2Department of Radiology, Ewha Womans University School of Medicine, Seoul, Korea. |
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Abstract |
Small cell lung cancer is characterized by an aggressive clinical course and a high tendency for early dissemination in spite of a good chemotherapy response. Topotecan is a topoisomerase I inhibitor, and it is used as second-line treatment for small cell lung cancer. The reported dose-limiting adverse reactions to topotecan are mainly hematologic. Yet pulmonary toxicity associated with topotecan is known to be rare. We report here on a case that showed the development of acute respiratory distress syndrome during the 3rd cycle of topotecan chemotherapy in a patient with small cell lung cancer. He developed dyspnea and respiratory failure, and the chest CT scan revealed diffuse ground-glass opacity that was probably due to chemotherapy-related pulmonary toxicity. He finally died of acute respiratory distress syndrome. |
Key Words:
Small cell carcinoma, Topotecan, Acute respiratory distress syndrome |
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