| Phase II Study of Irinotecan Plus Cisplatin as First Line therapy in Extensive Small-Cell Lung Cancer. |
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Ki Eun Hwang, So Young Kim, Jong Hoon Jung, Seong Hoon Park, Jung Hyun Park, Hwi Jung Kim, Hak Ryul Kim, Sei Hoon Yang, Eun Taik Jeong |
1Department of Internal Medicine, College of Medicine, Wonkwang University, Iksan, Korea. jetpul@wonkwang.ac.kr
2Department of Radiology, College of Medicine, Wonkwang University, Iksan, Korea. |
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| Abstract |
BACKGROUND
Irinotecan (topoisomerase I inhibitor) is effective as a monotherapy against small-cell lung cancer(SCLC). Cisplatin is also an important drug against SCLC. A phase II study of irinotecan combined with cisplatin was carried out to evaluate the efficacy and toxicity of this combined regimen as a first line treatment in patients with extensive SCLC. METHODS: Thirty-nine patients with previously untreated extensive SCLC were enrolled in this study. Irinotecan 60mg/m(2) was administered intravenously on days 1, 8 and 15, and in combination with cisplatin 60mg/m(2) on day 1 and every 28 days thereafter. Four cycles of chemotherapy were given to the patients. RESULTS: The overall response rate was 77% with a complete response (CR) rate of 8%. The median survival time, 1- and 2-year survival rate were 14.8 months, 60.9% and 27.6%, respectively. The median progression free survival time, 6-and 12-month progression free survival rate were 8.4 months, 75% and 18.8%, respectively. The WHO grade 3 or more toxicity encountered were leukopenia (23%), diarrhea (26%). Two patients changed their chemotherapeutic regimen and one patient died from severe diarrhea. CONCLUSION: The combination of irinotecan and cisplatin is effective as a first line therapy in extensive SCLC is effective , but has severe or fatal diarrhea as toxicity. |
| Key Words:
Small-cell lung cancer, Irinotecan, Cisplatin |
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