A Case of Unknown Primary Malignant Melanoma with Pulmonary and Endobronchial Metastasis.

Min, Young Hoon; Kim, Sung Wook; Chin, Hui Jong; Lee, Tae Yoo; Song, Hun Ho; Lee, Keun Seok; Lee, Jung Ae; Park, Young Lee; Hyun, In Gyu

doi:2002.53.2.196

Tuberc Respir Dis > Volume 53(2); 2002 > Article

Case Report

Tuberculosis and Respiratory Diseases 2002;53(2):196-201.
DOI: https://doi.org/10.4046/trd.2002.53.2.196 Published online August 1, 2002.

A Case of Unknown Primary Malignant Melanoma with Pulmonary and Endobronchial Metastasis.

Young Hoon Min, Sung Wook Kim, Hui Jong Chin, Tae Yoo Lee, Hun Ho Song, Keun Seok Lee, Jung Ae Lee, Young Lee Park, In Gyu Hyun

Department of Internal Medicine, College of Medicine, Hallym University, Chunchon, Korea. youngiee@dreamwiz.com

Abstract

Malignant melanoma is a highly malignant form of cutaneous cancer derived from melanocytes. The lesion frequently metastasizes to the lymph nodes, lung, liver and bone. However, an endobronchial metastasis and a primary malignant melanoma of the lung are quite rare. We report a case of an unknown primary malignant melanoma with a pulmonary and endobronchial metastasis in a 34 years old male. He complained of coughing and black-colored sputum. Abnormal skin and mucosal lesions were not found during a physical examination. A chest X-ray revealed multiple nodular masses in both lung fields. A flexible bronchoscopy showed two yellowish small nodules at the entry of left lower bronchus. Vimentin, the S-100 protein, and HMB-45 stain positive melanoma cells were detected at the bronchoscopic biopsy specimen.

Key Words: Malignant melanoma, Endobronchial metastasis