A Case of Acute Interstitial Pneumonia with Invasive Pulmonary Aspergillosis.

Lee, Young Min; Yoon, Hye Kyoung; Kim, Joo In

doi:2002.52.1.62

Tuberc Respir Dis > Volume 52(1); 2002 > Article

Case Report

Tuberculosis and Respiratory Diseases 2002;52(1):62-69.
DOI: https://doi.org/10.4046/trd.2002.52.1.62 Published online January 1, 2002.

A Case of Acute Interstitial Pneumonia with Invasive Pulmonary Aspergillosis.

Young Min Lee, Hye Kyoung Yoon, Joo In Kim

¹Department of Internal Medicine, Inje University, College of Medicine, Busan, Korea. lym066@chollian.net
²Department of Internal Anatomic Pathology, Inje University, College of Medicine, Busan, Korea.

Abstract

Acute interstitial pneumonia (AIP) is a rare fulminant form of lung injury that presents acutely; usually in a previously healthy individual. It corresponds to a subset of cases of idiopathic adult respiratory distress sy ndrome (ARDS). Invasive pulmonary aspergillosis is a disease occuring predominantly with defects in immunity such as hematologic malignancy, influenza infection, postchemotherapy, long-term corticosteroid treatment. Invasive aspergillosis has worse prognosis and most cases are diagnosed at postmortem autopsies. We experienced a case of acute interstitial pneumonia with an invasive aspergillosis during corticosteroid treatment. Acute interstitial pneumonia with invasive aspergillosis was diagnosed by an open lung biopsy using thoracoscopy, showing fungal hyphae with sepsis and an acute angle branching invasion of the lung tissue and blood vessels. The patient was treated with IV amphotericin-B, but died due to septic shock.

Key Words: Acute interstitial pneumonia, Invasive pulmonary aspergillosis, Corticosteroid