A Case of Pulmonary Eosinophilic Granuloma in a Passive-Smoking Reproductive Female.

Shin, Jae Ho; Kim, Ji Young; Oh, Soo Hwan; Park, Hong Soo; Chung, Sang Su; Na, Sang Kyu; Kim, Hyung Jung; Ahn, Chul Min; Kim, Hae Kyun; Kim, Sang Jin; Cho, Sang Ho

doi:1998.45.2.421

Tuberc Respir Dis > Volume 45(2); 1998 > Article

Case Report

Tuberculosis and Respiratory Diseases 1998;45(2):421-428.
DOI: https://doi.org/10.4046/trd.1998.45.2.421 Published online April 1, 1998.

A Case of Pulmonary Eosinophilic Granuloma in a Passive-Smoking Reproductive Female.

Jae Ho Shin, Ji Young Kim, Soo Hwan Oh, Hong Soo Park, Sang Su Chung, Sang Kyu Na, Hyung Jung Kim, Chul Min Ahn, Hae Kyun Kim, Sang Jin Kim, Sang Ho Cho

¹Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Korea.
²Department of Thoracic Surgery, College of Medicine, Yonsei University, Seoul, Korea.
³Department of Radiology, College of Medicine, Yonsei University, Seoul, Korea.
⁴Department of Pathology, College of Medicine, Yonsei University, Seoul, Korea.

Abstract

Pulmonary eosinophilic granuloma, a rare form of Langerhans cell histiocytosis confined to lung, has no known etiology and variable natural history. It is characterized by discrete proliferation of Langerhans cells. It is known that over 90% of the patients are cigarette smokers, and it is rarely reported in non- or passive-smoking patients, especially female. Here we describe a case of pulmonary eosinophilic granuloma in a passive-smoking, reproductive female patient presented with spontaneous pneumothorax. We identified S-100 and CDla positive histiocytes on immunohistochemical stain of the lung tissue obtained by open lung biopsy.

Key Words: Pulmonary eosinophilic granuloma, Langerhans cell histiocytosis