The effect of quinolyl piperazine phosphate on the silicotic rats.

Yim, Hyeon Woo; Jung, Chang Young; Oh, Sang Yang; Kim, Kyung Ah; Lim, Young; Yun, Im Goung; Roh, Young Man

doi:1993.40.2.112

Tuberc Respir Dis > Volume 40(2); 1993 > Article

Original Article

Tuberculosis and Respiratory Diseases 1993;40(2):112-122.
DOI: https://doi.org/10.4046/trd.1993.40.2.112 Published online April 1, 1993.

The effect of quinolyl piperazine phosphate on the silicotic rats.

Hyeon Woo Yim¹, Chang Young Jung¹, Sang Yang Oh¹, Kyung Ah Kim¹, Young Lim¹, Im Goung Yun¹, Young Man Roh²

¹Department 0f Occupational Disease, Catholic University Medical College. Seoul, Korea
²Catholic lndustrial Medical Center

Quinolyl Piperazine Phosphate가 흰쥐 규폐증에 미치는 영향*

Abstract

Backgrounds
The goal of drug therapy in pneumoconiosis is to inhibit the progression of pulmonary fibrosis related to a toxic effect of the inhaled substance. Although there have been many studies on the therapy of pneumoconiosis, it is still elusive. Quinolyl piperazi ne phosphate (QP) , a derivative of chloroquine, is less toxic, more effective, and longer action than chloroquine. This investigation was performed to examine the effect of the quinolyl piperazine phosphate in silicotic rats.
Methods
The silica group was administered intratracheally by 40 mg free silica dust with 0.5 ml normal saline, and the QP group was orally administered QP 10 mg per 、.veek after free silica instillation. The animals in the silica group and the QP group were killed at the 1st, 3rd, 8th and 20th week after free silica instillation. We observed the total cell count in bronchoalveolar lavage fluid, luminol-dependent chemiluminescence by viable alveolar inflammatory cells. the dry weights and the amount of hydroxyproline in the left lung and the histopathologic examination in the right lung.
Results
1) The total number of cells of bronchoalveolar lavage fluid in the QP group tended to be decreased in comparison with the silical group. But, It was not significant. 2) Luminol-induced chemiluminescence by viable alveolar inflammatory cells in the QP group was similiar to that in the silical group. 3) The dry we ights in the left lung at the 3th and 8th week in the QP group were significantly decreased compared to the silical group. 4) The total amount of hydroxyproline at the 3rd week of the QP group were significantly decreased compared to the silical group. In the silica group, the total amount of hydroxyproline was significantly increased at the 3rd week compared with the 1st group. But, in the QP group, it was significantly increased at the 8th week. 5) In tissue pathology, the infiltration of inflammatory cells around bronchiole, and the number and the size of silicotic nodule in the QP group were similar to the silica group. But, the extent of fibrosis is less than the silica group _ Especially we observed progressive massive fibrosis which located in the periphery in 3 cases among the silica group, but couldn’t observe in the QP group.
Conclusions
QP doesn’t significantly suppress the pulmonary fibrosis consequent to the intratracheal instillation of free silica dust, but delay the progression of fibrosis.

Key Words: Silicosis, Quinolyl piperazine phosphate