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Tuberc Respir Dis > Volume 38(2); 1991 > Article
Original Article
Tuberculosis and Respiratory Diseases 1991;38(2):135-142.
DOI: https://doi.org/10.4046/trd.1991.38.2.135    Published online June 1, 1991.
Clinical study on mesothelioma of the pleura.
Tae Sun Shim, Ho Joong Kim, Hyung Seok Choe, Hyuk Pyo Lee, Ji Young Seo, Young Whan Kim, Young Soo Shim, Keun Youl Kim, Yong Chol Han
Department of Internal Medicine and Tuberculosis Researrch Institute, Seoul National University College of Medicine, Seoul, Korea
Abstract
We reviewed 15 cases of mesothelioma of the pleura, of which three cases were localized benign form and 12 cases were malignant diffuse form. The tumors were distributed equally in both sexes, and occurred most commonly in fifth to seventh decades. The history of exposure to asbestos was present in only one case. The chief complaints were mainly chest pain and dyspnea. Associated symptoms were cough, sputum, hemoptysis, weight loss, anorexia, chill. On physical examination, unilateral, decreased breathing sound was main feature. The simple chest radiograph showed masses in all localized mesotheliomas (100%) and in 2 diffuse mesotheliomas (17%). 8 cases of diffuse mesotheliomas (67%) showed unilateral pleural effusions. Pleural effusions were mainly bloody (67%), and almost all were exudates. In all localized mesotheliomas, final diagnosis was made by open thoracotomy. In diffuse mesotheliomas, final diagnosis was made by open thoracotomy in 7 cases, chest wall mass biopsy in 2 cases, thoracoscopic biopsy in 1 case, pleural biopsy in 1 case, and pleural biopsy combined with axillary Iymph node biopsy in 1 case. Localized mesotheliomas were treated by simple excision with good prognosis. In diffuse mesotheliomas, surgical treatment (pleuropneumonectomy, pleurectomy), chemotherapy, or radiotherapy, alone or in combination, were used with dismal prognosis. The prognostic factors were not found due to the small number of cases, incomplete follow up, and early drop out.
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