Angiotensin Converting Enzyme in Human Adult Respiratory Distress Syndrome

Han, Dong Cheol; Yang, Dong Ho; Kim, Tae Jun; Hwang, Sung Gyu; Park, Choon Sik; Kong, Hyun Ho; Sim, Young Soo; Han, Yong Chul

doi:1985.32.1.46

Tuberc Respir Dis > Volume 32(1); 1985 > Article

Original Article

Tuberculosis and Respiratory Diseases 1985;32(1):46-53.
DOI: https://doi.org/10.4046/trd.1985.32.1.46 Published online March 1, 1985.

Angiotensin Converting Enzyme in Human Adult Respiratory Distress Syndrome

Dong Cheol Han¹, Dong Ho Yang¹, Tae Jun Kim¹, Sung Gyu Hwang¹, Choon Sik Park¹, Hyun Ho Kong², Young Soo Sim², Yong Chul Han²

¹Department of Internal Medicine, Soon Chun Hyang University, School of Medicine, Seoul, Korea
²Department of Internal Medicine, Seoul National university, Collge of Medicine, Seoul, Korea

성인성 호흡장애 증후군에서의 angiotensin converting enzyme

한동철¹, 양동호¹, 김태준¹, 황성규¹, 박춘식¹, 공헌호², 심영수², 한용철²

Abstract

Angiotensin converting enzyme (ACE) is almost entirely derived from pulmonary endothelium and the activity of ACE could be used as an index of the pulmonary endothelial damage. We measured the ratio of arterial oxygen partial pressure to inspired oxygen fraction(PaO₂/FiO₂) and serum ACE levels in 16 patients with adult respiratory distress syndrome (ARDS) daily from day 1 to 7 on ventilator to study correlation between ACE and PaO₂/FiO₂ and the predictive value of ACE in 7 patients with sepsis and 7 patients with high pressure edema and to study value of ACE in the differential diagnosis between sepsis with or without ARDS and between ARDS and high pressure pulmonary edema. Our data is shown: Serum ACE and PaO₂/FiO₂ were not correlated(r = - 0.04, P> 0.1 ). The result of this study suggests that serum ACE level may be useful in differential diagnosis between sepsis with or without ARDS and between ARDS and high pressure pulmonary edema but have no prognostic value in predicting survival or death of a patient with ARDS.