A Study on the 2.3-DPG(Diphosphoglycerate) Activity in Red Blood Cells of the Patients with Bronchial Asthma, COPD (Chronic Obstructive Pulmonary Disease) and Pulmonary Tuberculosis

Kim, Jeong Kwon; Lee, Choong Seob; Lee, Yong Chul; Lee, Soo Yeong; Song, Ha Sook; Lee, Yang Geun

doi:1990.37.1.93

Tuberc Respir Dis > Volume 37(1); 1990 > Article

Original Article

Tuberculosis and Respiratory Diseases 1990;37(1):93-99.
DOI: https://doi.org/10.4046/trd.1990.37.1.93 Published online March 1, 1990.

A Study on the 2.3-DPG(Diphosphoglycerate) Activity in Red Blood Cells of the Patients with Bronchial Asthma, COPD (Chronic Obstructive Pulmonary Disease) and Pulmonary Tuberculosis

Jeong Kwon Kim, Choong Seob Lee, Yong Chul Lee, Soo Yeong Lee, Ha Sook Song, Yang Geun Lee

Department of Internal Medicine, Chonbuk National University College of Medicine, Chon Buk, Korea

기관지 천식, 만성폐쇄성 폐질환, 폐결핵 환자의 적혈구내 2.3-DPG(Diphosphoglycerate)활성도에 대한 연구

김정권, 이충섭, 이용철, 이수영, 송하숙, 이양근

Abstract

Red blood cells synthesize 2.3- DPG that shifts the oxygen dissociation curve to right and consequently, increase the oxygen utilization and metabolism in the peripheral tissue. Recently there are many reports on the 2.3- DPG activity in red blood cell and related factor, ie PH, Temperature hemuglobin, anoxia, bicarbonate, and high altitude. On these fundament al basis. clinically 1 investigate the relationship between 2.3- DPG activity in red blood cell and known environmental factors in bronchial astsma, COPD and pulmonary tuberculosis. The result doesn’t show significant change of 2.3-DPG activity according to each disease. its duration, and its severity. But, it shows a correlation between 2.3- DPG activity and environmental fact ors‘ Especially a arterial oxygen partial pressure shows a reverse correlation with 2.3-DPG activity. These results suggest that 2.3-DPG activity mainly depends on the arterial oxygen partial pressure.