Levofloxacin and Torsades de Pointes. |
Se Ah Kwon, Cheol Hong Kim, Won Jun Song, Ja Kyung Koo, Soon Jae Lee, Ji Young Park, In Gyu Hyun, Jang Hyu Ko, Hyun Soo Kim |
1Department of Internal Medicine, Hallym University College of Medicine, Seoul, Korea. kimch2002@hallym.or.kr 2Department of Plastic and Reconstructive Surgery, Hallym University College of Medicine, Seoul, Korea. 3Department of Laboratory Medicine, Hallym University College of Medicine, Seoul, Korea. |
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Abstract |
Torsades de pointes associated with a prolonged QT interval is a life-threatening arrhythmia, which may be induced by any of the following: drugs, electrolyte imbalances, severe bradycardia and intracranial hemorrhage. Torsades de pointes is characterized by beat-to-beat variations in the QRS complexes in any ECG leads with rates of 200~250 per minute. Fluoroquinolones are widely used and well tolerated antibacterial agents. However, prolongation of the QT interval leads rarely to Torsades de pointes as a significant adverse effect. So, it should be used with caution in high-risk patients for developing Torsades de pointes. We report one case of 67-year old man with contact burns who experienced Torsades de pointes, which probably resulted from the use of levofloxacin, and no further episode occurred after its withdrawal. |
Key Words:
levofloxacin, Torsades de Pointes |
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