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Original Article
COPD
Clinical Significance of Various Pathogens Identified in Patients Experiencing Acute Exacerbations of COPD: A Multi-center Study in South Korea
Hyun Woo Ji, Soojoung Yu, Yun Su Sim, et al.
Tuberc Respir Dis. 2025;88(2):292-302.   Published online December 30, 2024
Background: Respiratory infections play a major role in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This study assessed the prevalence of bacterial and viral pathogens and their clinical impact on patients with AECOPD. Methods: This retrospective study included 1,186 patients diagnosed with AECOPD at 28 hospitals in South Korea between 2015 and 2018. We evaluated the identification rates of pathogens,...
Original Article
COPD
Kernel Conversion Improves the Correlation between the Extent of Emphysema and Clinical Parameters in Chronic Obstructive Pulmonary Disease: A Multicenter Cohort Study
Tai Joon An, Youlim Kim, Hyun Lee, et al.
Tuberc Respir Dis. 2025;88(2):303-309.   Published online February 4, 2025
Background: Computed tomography (CT) scans are utilized to assess emphysema, a prominent phenotype of chronic obstructive pulmonary disease (COPD). Variability in CT protocols and equipment across hospitals can impact accuracy. This study aims to implement kernel conversion across different CT settings and evaluate changes in the correlation between the emphysema index pre- and post-kernel conversion, along with clinical measures in...
Original Article
COPD
Adherence to Pharmacological Management Guidelines for Stable Chronic Obstructive Lung Disease
Sang Min Han, Hyo Seon Kim, Seung Yong Park, et al.
Tuberc Respir Dis. 2025;88(2):310-321.   Published online February 6, 2025
Background: This study evaluated adherence to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) and Korean guidelines in the prescription patterns of respiratory specialists for stable chronic obstructive pulmonary disease (COPD) management. Methods: Data were collected on medications from 2011 to 2022 using the Korea COPD Subtype Study (KOCOSS) cohort. Patients were divided into two groups: those registered before and...
Original Article
COPD
Management of Chronic Obstructive Pulmonary Disease in Vietnam during the COVID-19 Period: Current Situation and Challenges
Thuy Thanh Phan, Giap Van Vu, Chau Quy Ngo
Tuberc Respir Dis. 2025;88(2):322-333.   Published online February 7, 2025
Background: To assess the alterations in exacerbation rates, other clinical outcomes, and to identify persistent challenges in the management of chronic obstructive pulmonary disease (COPD) in Vietnamese COPD management units (CMUs). Methods: A multi-center, prospective cohort study was conducted on COPD within the CMUs of three study sites. The primary endpoint was exacerbation frequency. Data on demographic and clinical characteristics were...
Original Article
Lung Cancer
Better Chemotherapeutic Response of Small Cell Lung Cancer in Never Smokers than in Smokers
Ha-Young Park, Hyung-Joo Oh, Hwa Kyung Park, et al.
Tuberc Respir Dis. 2025;88(2):334-341.   Published online February 11, 2025
Background: Small cell lung cancer (SCLC) is called ‘smoker’s disease’ because it is strongly associated with smoking and most cases occur in smokers. However, it can also occur in never smokers. We investigated the clinical features of never smokers with SCLC and compared their treatment outcomes with those of smokers with SCLC. Methods: We retrospectively reviewed the clinical data of patients...
Original Article
Lung Cancer
Comparison of Anticancer Effects of Histone Deacetylase Inhibitors CG-745 and Suberoylanilide Hydroxamic Acid in Non-small Cell Lung Cancer
Hyo Jin Kim, Ui Ri An, Han Jee Yoon, et al.
Tuberc Respir Dis. 2025;88(2):342-352.   Published online February 13, 2025
Background: Histone deacetylase (HDAC) inhibition offers potential anticancer effects across diverse cancers due to HDAC's significant role in cancer development and progression. Consequently, we demonstrated the therapeutic efficacy of the novel HDAC inhibitor, CG-745, in comparison with existing inhibitors such as suberoylanilide hydroxamic acid (SAHA) in non-small cell lung cancer (NSCLC) cells. Methods: CG-745's effect on apoptosis and reactive oxygen species...
Original Article
Tuberculosis
Bibliometric Analysis of Nontuberculous Mycobacteria Research in South Korea
Geunin Lee, Young Ae Kang, Youngmok Park
Tuberc Respir Dis. 2025;88(2):353-360.   Published online January 14, 2025
Background: Current research on nontuberculous mycobacteria (NTM) is multidisciplinary, necessitating proper organization to obtain comprehensive insight. Therefore, a bibliometric analysis was performed to identify NTM research characteristics in South Korea. Methods: The Web of Science was searched for NTM articles authored by Koreans at Korean institutions until March 2023. We collected data on authors, publication year, article type, study design, research...
Original Article
Critical Care Medicine
Prevalence of New Frailty at Hospital Discharge in Severe COVID-19 Survivors and Its Associated Factors
Jong Hwan Jeong, Manbong Heo, Sunghoon Park, et al.
Tuberc Respir Dis. 2025;88(2):361-368.   Published online December 5, 2024
Background: The development of frailty at hospital discharge affects the clinical outcomes in severe coronavirus disease 2019 (COVID-19) survivors who had no frailty before hospitalization. We aimed to describe the prevalence of new frailty using the clinical frailty scale (CFS) and evaluate its associated factors in patients with severe COVID-19 without pre-existing frailty before hospitalization. Methods: We performed a secondary analysis...
Original Article
Critical Care Medicine
Relationship between the Geriatric Nutrition Risk Index and the Prognosis of Severe Coronavirus Disease 2019 in Korea
Hye Ju Yeo, Daesup Lee, Mose Chun, et al.
Tuberc Respir Dis. 2025;88(2):369-379.   Published online January 6, 2025
Background: Malnutrition exacerbates the prognosis of numerous diseases; however, its specific impact on severe coronavirus disease 2019 (COVID-19) outcomes remains insufficiently explored. Methods: This multicenter study in Korea evaluated the nutritional status of 1,088 adults with severe COVID-19 using the Geriatric Nutritional Risk Index (GNRI) based on serum albumin levels and body weight. The patients were categorized into two groups: GNRI...
Original Article
Critical Care Medicine
Understanding of Patients with Severe COVID-19 Using Lung Ultrasound
Seo-Hee Yang, Eun Ju Park, Jung-Hyun Kim, et al.
Tuberc Respir Dis. 2025;88(2):380-387.   Published online January 6, 2025
Background: Lung ultrasound (LUS) has proven valuable in the initial assessment of coronavirus disease 2019 (COVID-19), but its role in detecting pulmonary fibrosis following intensive care remains unclear. This study aims to assess the presence of pulmonary sequelae and fibrosis-like changes using LUS in survivors of severe COVID-19 pneumonia one month after discharge. Methods: We prospectively enrolled patients with severe COVID-19...
Original Article
Miscellaneous
Features of Lung Cyst in Birt-Hogg-Dubé Syndrome from Patients with Multiple Lung Cysts
Yong Jun Choi, Hye Jung Park, Chi Young Kim, et al.
Tuberc Respir Dis. 2025;88(2):388-398.   Published online November 25, 2024
Background: High-resolution chest computed tomography (CT) is a crucial assessment tool for diagnosing Birt-Hogg-Dubé (BHD) syndrome. This study aimed to analyze differences of lung cysts between BHD and other cystic lung diseases. Methods: From January 2020 to December 2022, patients with multiple lung cysts who underwent chest CT at Gangnam Severance Hospital were included. Results: Over a 3-year period (from January 2020...
Original Article
Miscellaneous
Increased Neutrophil Elastase in Affected Lobes of Bronchiectasis and Correlation of Its Levels between Sputum and Bronchial Lavage Fluid
Lam Nguyen-Ho, Hoang Kim Tu Trinh, Vu Le-Thuong, et al.
Tuberc Respir Dis. 2025;88(2):399-407.   Published online January 14, 2025
Background: Neutrophil elastase (NE) has been proposed as a potential biomarker for evaluating the severity and prognosis of bronchiectasis. This study aimed to compare bronchial lavage quantification of NE levels and activities with those of sputum. Methods: A cross-sectional study was conducted in which 24 Vietnamese adults with bronchiectasis were enrolled from June 2023 to August 2023. All participants underwent bronchoscopy...
Current Issue
Volume 88(2); Apr 2025

Tuberculosis and
Respiratory Diseases

Print ISSN: 1738-3536
Online ISSN: 2005-6184

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