Tuberculosis and Respiratory Diseases

Original Article

Asthma

Real-World Safety of Fluticasone Furoate/Umeclidinium/Vilanterol in Patients with Asthma or Chronic Obstructive Pulmonary Disease (COPD), and Clinical Outcomes in COPD: Post-marketing Surveillance in Korea

Eun-Bin Lee, Jung-Eun Cho, Eunsun Kwon, et al.

Tuberc Respir Dis. 2026;89(4):464-479. Published online June 12, 2026

Background: Fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) is a single-inhaler triple therapy administered via the ELLIPTA inhaler (GSK). FF/UMEC/VI 100/62.5/25 μg was approved in Korea to treat chronic obstructive pulmonary disease (COPD) in 2018 and asthma in 2022 (100/62.5/25 and 200/62.5/25 μg). Safety and efficacy of FF/UMEC/VI are well established in global clinical trials, though Korean real-world evidence remains limited. Methods: This Korean multicentre...

DOI: https://doi.org/10.4046/trd.2025.0158

Original Article

Bronchiectasis

Blood Eosinophil Count, Disease Severity, and Exacerbation Risk in Korean Patients with Bronchiectasis: A Retrospective Cohort Study

Sun-Hyung Kim, Dong Eun Kye, Geun-Hyeong Kim, et al.

Tuberc Respir Dis. 2026;89(4):480-490. Published online July 2, 2026

Background: Peripheral blood eosinophil counts have been associated with bronchiectasis outcomes, but findings remain inconsistent, and their role in acute exacerbations among Korean patients is unclear. Methods: This study retrospectively evaluated 491 patients with bronchiectasis at a tertiary hospital in Korea between 2014 and 2021. Using a negative binomial regression model adjusted for follow-up duration, we evaluated the association between peripheral...

DOI: https://doi.org/10.4046/trd.2025.0219

Original Article

COPD

Visualizing Three Decades of Chronic Obstructive Pulmonary Disease and Airway Mucus Hypersecretion Research: A Bibliometric Analysis (1994–2024)

Naer An, Dongmei Wang, Dan Xu, et al.

Tuberc Respir Dis. 2026;89(4):491-505. Published online July 20, 2026

Background: Chronic obstructive pulmonary disease (COPD) is a condition with high prevalence and mortality, causing a substantial disease burden. Airway mucus hypersecretion (AMH) is clinically associated with impaired pulmonary function, diminished quality of life, and increased mortality in COPD patients. The purpose of this bibliometric research was to identify research developments and emerging hotspots within the field of AMH and...

DOI: https://doi.org/10.4046/trd.2025.0199

Original Article

COPD

Development of a Screening Model for Exercise-Induced Desaturation by Machine Learning Method

Seung Ju Kim, Jae Ha Lee, Ji-Yong Moon, et al.

Tuberc Respir Dis. 2026;89(4):506-516. Published online July 20, 2026

Background: Exercise-induced desaturation (EID) during the 6-minute walk test (6MWT) is an established marker of adverse outcomes in patients with chronic obstructive pulmonary disease (COPD). Therefore, we aimed to develop a machine learning approach focused on screening to identify patients at increased risk of EID. Methods: We analyzed data from the nationwide, multicenter Korea COPD Subgroup Study. EID was defined as...

DOI: https://doi.org/10.4046/trd.2026.0041

Original Article

Interstitial Lung Disease

Nationwide Incidence and Prevalence of Idiopathic Pulmonary Fibrosis in South Korea

Hee-Young Yoon, Kyung Hoon Kim, Song Yee Kim, et al.

Tuberc Respir Dis. 2026;89(4):517-528. Published online June 25, 2026

Background: Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with high mortality. Population-based data on long-term epidemiological trends and real-world treatment outcomes in Asia remain limited. This study described national trends in IPF prevalence and incidence in South Korea and evaluated pirfenidone use and associated mortality. Methods: Using the Korean National Health Insurance Service customized research database, we identified...

DOI: https://doi.org/10.4046/trd.2026.0012

Original Article

Interstitial Lung Disease

A Multicenter Registry for Rare Interstitial Lung Diseases in Korea: Baseline Characteristics and Clinical Outcomes

Ju Hyun Oh, Jae Ha Lee, Sung Woo Park, et al.

Tuberc Respir Dis. 2026;89(4):529-541. Published online June 24, 2026

Background: Rare interstitial lung diseases (ILDs) are a heterogeneous group of diffuse parenchymal lung disorders with low prevalence and diverse etiologies that pose diagnostic and therapeutic challenges. We aimed to establish a nationwide, multicenter registry of rare ILDs in South Korea to characterize their clinical features and outcomes. Methods: We conducted a multicenter, observational cohort study involving 304 patients with rare...

DOI: https://doi.org/10.4046/trd.2026.0004

Original Article

Interstitial Lung Disease

Single-Cell Analysis Identifies Factors Associated with Rheumatoid Arthritis-Related Interstitial Lung Disease in Comparison with Idiopathic Pulmonary Fibrosis

Dongjun Kim, Hyun Lee, Sang-Heon Kim, et al.

Tuberc Respir Dis. 2026;89(4):542-552. Published online July 28, 2026

Background: Interstitial lung disease (ILD) is a common but serious extra-articular manifestation of rheumatoid arthritis (RA). RA-associated ILD (RA-ILD), which often presents with the usual interstitial pneumonia pattern, can resemble idiopathic pulmonary fibrosis (IPF), though the treatment and progression of these two conditions differ. However, the immunologic and molecular mechanisms associated with RA-ILD and IPF development have not been well...

DOI: https://doi.org/10.4046/trd.2026.0085

Original Article

Pulmonary Infection

Changing Epidemiology of Severe Pneumococcal Pneumonia in Adults at a Tertiary Hospital between 2010 and 2024

Sang-Ho Choi, Jin Won Huh, Sang-Bum Hong, et al.

Tuberc Respir Dis. 2026;89(4):553-563. Published online August 10, 2026

Background: The epidemiology of pneumococcal pneumonia can be influenced by vaccine implementation, serotype replacement, and viral circulation. We aimed to investigate 15-year trends in the epidemiological and clinical characteristics of severe pneumococcal pneumonia patients requiring intensive care unit (ICU) admission. Methods: We analyzed data from a prospective cohort of adult patients with severe pneumonia admitted to the 28-bed medical ICU of...

DOI: https://doi.org/10.4046/trd.2026.0003

Current Issue: Volume 89(4); Oct 2026

Tuberculosis and
Respiratory Diseases

Print ISSN: 1738-3536
Online ISSN: 2005-6184

Impact Factor

3.6

45,830	Tissue Adequacy and Diagnostic Yield Assessment in Malignant Lymph Nodes Using Endobronchial Ultrasound (EBUS)-Guided Miniforcep Biopsy vs. EBUS-Guided Transbronchial Needle Aspiration
7,285	Korean Clinical Practice Guidelines for Interstitial Lung Disease: Part 2. Idiopathic Pulmonary Fibrosis
7,634	Post-tuberculosis Health: A Holistic Perspective on Multisystem Sequelae and Long-Term Wellbeing
14,318	Comprehensive Strategies for Preoperative Pulmonary Risk Evaluation and Management
5,507	Small Airway Dysfunction in Chronic Obstructive Pulmonary Disease Pathology: Assessment and Clinical Implications

Cited By 43	Economic Burden of Chronic Obstructive Pulmonary Disease: A Systematic Review
Cited By 24	Proposed Etiotypes for Chronic Obstructive Pulmonary Disease: Controversial Issues
Cited By 22	Disease Severity and Activity in Bronchiectasis: A Paradigm Shift in Bronchiectasis Management
Cited By 21	Tuberculosis Notification and Incidence: Republic of Korea, 2022
Cited By 17	Comprehensive Strategies for Preoperative Pulmonary Risk Evaluation and Management