Tuberc Respir Dis > Volume 64(6); 2008 > Article
Tuberculosis and Respiratory Diseases 2008;64(6):422-426.
DOI:    Published online June 1, 2008.
Detection of Clarithromycin-resistant Strains from Clinical Isolates of Mycobacterium abscessus.
Seung Heon Lee, Young Kil Park, Sung Weon Ryo, Myung Sup Shim, Woo Jin Lew, Hee Jin Kim
Korean Institute of Tuberculosis, Seoul, Korea.
Mycobacterium abscessus is the most pathogenic and drug-resistant rapid-growing mycobacterium. Clarithromycin or azithromycin are the only regular oral antimycobacterial agents that have an effect on M. abscessus. We tried to detect the clarithromycin-resistant strains from the clinical isolates of M. abscessus. METHODS: We tried to isolate the clarithromycin-resistant strains from 220 clinical isolates of M. abscessus by performing using reverse hybridization assay (RHA) and the broth microdilution test (BMT). RESULTS: Seven resistant strains (3.2%) from all the tested clinical isolates were detected by BMT. Three of these resistant strains were also detected by RHA and it was confirmed that they had point mutants. CONCLUSION: These results showed that clarithromycin resistance in M. abscessus clinical isolates is related to a point mutation and other unknown mechanisms.
Key Words: Mycobacterium abscessus, Reverse hybridization assay, Broth microdilution test, 23S rRNA, Clarithromycin

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