Fatal Tumor Lysis Syndrome During Chemotherapy in Small Cell Lung Cancer.

Kook, Eun Hee; Kim, Min Soo; Ahn, Se Han; Jeon, Se Young; Yoon, Jung Ho; Han, Min Sung; Kim, Cheol Hyeon; Lee, Jae Cheol

doi:2008.64.3.215

Tuberc Respir Dis > Volume 64(3); 2008 > Article

Case Report

Tuberculosis and Respiratory Diseases 2008;64(3):215-218.
DOI: https://doi.org/10.4046/trd.2008.64.3.215 Published online March 1, 2008.

Fatal Tumor Lysis Syndrome During Chemotherapy in Small Cell Lung Cancer.

Eun Hee Kook, Min Soo Kim, Se Han Ahn, Se Young Jeon, Jung Ho Yoon, Min Sung Han, Cheol Hyeon Kim, Jae Cheol Lee

Department of Internal Medicine, Korea Cancer Center Hospital, Seoul, Korea. jclee@kcch.re.kr

Abstract

Tumor lysis syndrome is a life-threatening complication of anti-cancer therapy that typically occurs in patients with large, rapidly growing and treatment-sensitive tumors such as high-grade lymphomas and acute leukemias. However, its incidence in solid tumors has been known to be very low. Tumor lysis syndrome in solid tumors has a high mortality rate owing to the lack of prophylactic therapy to prevent this complication. We report a case of fatal tumor lysis syndrome developed during chemotherapy in extensive-stage small cell lung cancer, along with a brief review of the relevant literature considering the rarity of this manifestation in solid tumor.

Key Words: Small cell lung cancer, Tumor lysis syndrome