Pulmonary Thromboembolism after Post-menopause Hormonal Replacement Therapy. |
Sun Young Kim, Jong Hyeok Park, Hyun Kyung Lee, Hyuk Pyo Lee, Hye Kyung Lee, Soo Jeon Choi, Ho Kee Yum |
1Department of Internal Medicine, Inje University, Seoul, Korea. pulho@korea.com 2Department of Pathology, Inje University, Seoul, Korea. |
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Abstract |
Hormonal replacement therapy (HRT) has been proven for treatment of postmenopausal symptoms such as hot flushes, night sweats and urologic symptoms. HRT became very popular in the 1990's, when there were several reports showing that it also helped with other menopausal complications such as osteoporosis and cardiovascular disease. Recent studies report that the incidence of breast cancer, endometrial cancer, cerebral infarction, coronary artery diseases, deep vein thrombosis and pulmonary thrombembolism could rise after HRT. Among these side effects of HRT, the risk of pulmonary thromboembolism increases 2 to 4 fold after HRT, but can vary with the use of different doses and preparations. Here, we summarize the risk factors and clinical courses for 5 patients who developed pulmonary thromboembolism after postmenopausal HRT. |
Key Words:
Postmenopause hormone replacement therapy(HRT), Pulmonary thromboembolism, Deep vein thrombosis |
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