Tuberc Respir Dis > Volume 63(4); 2007 > Article
Tuberculosis and Respiratory Diseases 2007;63(4):346-352.
DOI:    Published online October 1, 2007.
Correlation Between NT-proBNP and Pulmonary Arterial Pressure in COPD Patients.
Yong Il Hwang, Geun Min Park, Sung Youn Kwon, Ho Il Yoon, Choon Taek Lee, Sung Koo Han, Young Soo Shim, Jae Ho Lee
1Department of Internal Medicine, Seoul National University, College of Medicine, Lung Institute of Seoul National University Medical Research Center, Korea.
2Medicine and Respiratory Center, Seoul National University Bundang Hospital, Seongnam, Korea.
Pulmonary hypertension is one of the cardiovascular complications of in COPD. However, a diagnosis of pulmonary hypertension requires an invasive test, such as right heart catheterization. NT-proBNP is a cardiac hormone that is elevated when a cardiac volume or pressure overload is present. It was hypothesized that NT-proBNP might play a role in detecting of pulmonary hypertension in COPD patients. METHOD: The 31 COPD patients, who underwent all of NT-proBNP, echocardiography, and spirometry in Seoul National University Bundang Hospital during the period from November 2003 to July 2005, were retrospectively analyzed. RESULT: Of the 31 COPD patients, 9 patients had pulmonary hypertension. A significant positive correlation was observed between the NT-proBNP and pulmonary arterial pressure (r=0.589, p=0.002). However, there was no significant correlation observed between the FEV(1) and NT-proBNP and FEV(1) and pulmonary arterial pressure. CONCLUSION: NT-proBNP might indicate the presence of pulmonary hypertension in COPD patients.
Key Words: Chronic obstructive pulmonary disease, Pulmonary hypertension, Natriuretic peptide, NT-proBNP

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