Tuberc Respir Dis > Volume 63(3); 2007 > Article
Tuberculosis and Respiratory Diseases 2007;63(3):294-298.
DOI:    Published online September 1, 2007.
A Case of Pulmonary Alveolar Proteinosis with Spontaneous Resolution.
Seung Bum Nam, Kwang Young Park, Ho Jin Lee, Jae Wook Jung, Yoon Hee Choi, Hyo Seok Kim, Cheol Hyeon Kim, Jae Cheol Lee
Department of Internal Medicine, Korea Cancer Center Hospital, Seoul, Korea.
Pulmonary alveolar proteinosis is a rare disorder that is characterized by the abundant accumulation of surfactant-derived material within the alveolar spaces and distal bronchioles. Although the findings of homogenous ground-glass opacities overlaid by thickened septa, which form a "crazy paving" pattern on high-resolution computed tomography, can assist in making a diagnosis, a lung biopsy is usually required. This disorder has a variable clinical course, from spontaneous resolution to respiratory failure and death. While a whole lung lavage has been the standard treatment since the early 1960s, GM-CSF therapy has been attempted based on the recently suggested pathogenetic mechanism. We report a case of pulmonary alveolar proteinosis that resolved spontaneously after an open lung biopsy.
Key Words: Pulmonary alveolar proteinosis, Spontaneous resolution

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