A Case of Pulmonary Sarcoidosis Combined with Neurosarcoidosis.

Park, Byung Hoon; Park, Seon Cheol; Shin, Sang Yun; Jeon, Han Ho; Jung, Kyung Soo; Jung, Woo Young; Byun, Min Kwang; Moon, Ji Ae; Kim, Young Sam; Kim, Se Kyu; Chang, Joon; Kim, Sung Kyu; Park, Moo Suk

doi:2007.62.6.549

Tuberc Respir Dis > Volume 62(6); 2007 > Article

Case Report

Tuberculosis and Respiratory Diseases 2007;62(6):549-553.
DOI: https://doi.org/10.4046/trd.2007.62.6.549 Published online June 1, 2007.

A Case of Pulmonary Sarcoidosis Combined with Neurosarcoidosis.

Byung Hoon Park, Seon Cheol Park, Sang Yun Shin, Han Ho Jeon, Kyung Soo Jung, Woo Young Jung, Min Kwang Byun, Ji Ae Moon, Young Sam Kim, Se Kyu Kim, Joon Chang, Sung Kyu Kim, Moo Suk Park

¹Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. uhs@hosp.sch.ac.kr
²The Institute of Chest Diseases, Yonsei University College of Medicine, Seoul, Korea.

Abstract

Sarcoidosis is a multi-systemic syndrome of an unknown etiology, and it is characterized by the formation of multiple noncaseating granulomas that disrupt the architecture and function of the tissues in which they reside. The most commonly affected organs are lung, skin and lymph nodes. Overt clinical involvement of the nervous system is uncommon and this occurs in about 5% of all patients during the course of their disease. The most common manifestations are granulomatous leptomeningitis, cranial nerve palsy, electrolyte or other endocrinologic abnormalities, but isolated memory impairment is a rare manifestation. This is a case of 59 years-old male with recent memory impairment, and he was previously diagnosed with pulmonary sarcoidosis by transbronchial lung biopsy. The brain MRI imaging revealed the leptomeningeal and parenchymal involvement of sarcoidosis. He was treated with high dose corticosteroid and his memory function was improved to nearly a normal level. We report here on a case of successful treatment of pulmonary sarcoidosis combined with neurosarcoidosis with using high dose corticosteroid, and the patient presented with recent memory impairment.

Key Words: Sarcoidosis, Neurosarcoidosis, Central nervous system