Tuberc Respir Dis > Volume 62(2); 2007 > Article
Tuberculosis and Respiratory Diseases 2007;62(2):125-128.
DOI:    Published online February 1, 2007.
A Case of Subungal Abscess and Onycholysis Induced by Docetaxel.
Han Young Jung, Chang Youl Lee, Hyung Jung Kim, Chul Min Ahn, Yoon Soo Chang
1Departments of Internal Medicine, The Yonsei University College of Medicine, Seoul, Korea.
2Institute of Chest Diseases, The Yonsei University College of Medicine, Seoul, Korea.
Docetaxel is a taxoid antineoplastic drug, which is widely used to treat locally advanced or metastatic non-small cell lung cancer (NSCLC). Among the adverse dermatological reactions, nail disorders such as bending, onycholysis, hypo- or hyperpigmentation are rare. We report a case of a 62-year-old male with advanced NSCLC (cT4N3M1, stage IV), who developed purulent discharge and onycholysis in the nail of all his fingers and the left great toe after five courses of anti-neoplastic chemotherapy, which included docetaxel (cumulative dose: 370 mg/m2, 590 mg). Seven days after the final session of chemotherapy, the patient had become aware of discoloration and swelling of the nail beds with out pain. Three days later, greenish-yellow purulent discharge oozed out from the involved nails. Microbiologic studies revealed Pseudomonas aeruginosa. Intravenous and topical antibiotics (mupirocin) were applied. After 2 weeks, regrown nails were observed and the onycholysis had improved.
Key Words: Docetaxel, Onycholysis, Subungal abscess

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