Tuberc Respir Dis > Volume 61(5); 2006 > Article
Tuberculosis and Respiratory Diseases 2006;61(5):440-446.
DOI:    Published online November 1, 2006.
Clinical Characteristics of Tuberculosis in Liver or Heart Transplant Recipients.
Hoon Jung, Yeon Mok Oh, Sang Do Lee, Woo Sung Kim, Dong Soon Kim, Won Dong Kim, Jae Joong Kim, Sung Gyu Lee, Tae Sun Shim
1Division of Pulmonary and Critical Care Medicine, and Division of Cardiology, Asan Medical Center, Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Korea.
2Division of Hepatopancreatobiliary Surgery and Liver Transplantation, Asan Medical Center, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Post-transplant tuberculosis (TB) is a serious complication in solid organ transplant recipients worldwide, However there is little or no data on TB in liver or heart transplant recipients in Korea. METHODS: The incidence and clinical characteristics of TB of 730 patients who had undergone a liver transplant in a university hospital in Korea between 1992 and 2004, and 110 heart transplant recipients in the same period, were reviewed retrospectively. RESULTS: The incidence of TB was 1.5%(11/730) and 2.7%(3/110) in the liver and heart transplantation, respectively. The median time from the transplant to the development of TB was 8.4 months(1.0-30.8). and the mean time from the symptoms to the diagnosis of TB was 2.1+/-3.6 months(0.3-13.2). Nine patients (65%) had pulmonary TB and five (35%) had extrapulmonary TB. The leukopenia and positive HbeAg at the baseline, post-transplant diabetes mellitus, and chronic rejection were associated with the development of TB in the liver transplant recipients. Ten patients were treated with a 4-drug standard regimen for a mean duration of 7.8+/-3.5 months. One patients died of TB. CONCLUSION: The incidence of TB in liver or heart transplant recipients was similar to that reported in other countries with a similar TB-burden.
Key Words: Tuberculosis, Liver transplantation, Heart transplantation

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