Tuberc Respir Dis > Volume 61(1); 2006 > Article
Tuberculosis and Respiratory Diseases 2006;61(1):26-33.
DOI:    Published online July 1, 2006.
Application of Noninvasive Positive Pressure Ventilation in Patients with Respiratory Failure.
Young Mi Seol, Young Eun Park, Seo Rin Kim, Jae Hyung Lee, Su Jin Lee, Ki Uk Kim, Jin Hoon Cho, Hye Kyung Park, Yun Seong Kim, Min Ki Lee, Soon Kew Park, Young Dae Kim
1Department of Internal Medicine, College of Medicine, Pusan National University, Busan, Korea.
2Department of Thorasic Surgery, College of Medicine, Pusan National University, Busan, Korea.
Noninvasive positive pressure ventilation(NPPV) has been increasingly used over the past decade in the management of acute or chronic respiratory failure and weaning of mechanical ventilation. We performed this clinical study to evaluate the usefulness of NPPV in patients who developed acute respiratory failure or post-extubation respiratory failure. METHODS: We analysed thirty four patients(sixteen males and eighteen females, mean ages 58 years) who applied NPPV(BIPAP S/T, Respironics co., USA) for respiratory failure or weaning difficulty at medical intensive care unit(MICU), emergency room and general ward of a tertiary hospital. We evaluated the underlying causes of respiratory failure, duration of treatment, the degree of adaptation, complication and predictive parameters of successful outcome. RESULTS: The overall success rate of NPPV was seventy-one percent. The duration of NPPV applying time, baseline blood pressure, pulse rate, respiration rate, PaO2, PaCO2, SaO2 were not different between success group and failure group. But, the baseline pH was higher in the success group. Predictors of success were higher baseline pH, patients with underlying disease of COPD, improvement of vital sign and arterial blood gas value after NPPV application. The success rate in patients with post-extubation respiratory failure was eighty percent. There were no serious complication on applying NPPV except minor complications such as facial skin erythema, abdominal distension & dry mouth. CONCLUSION: NPPV may be effective treatment in patients with acute respiratory failure or post-extubation respiratory failure in selected cases.
Key Words: Positive pressure ventilation, Intubation, COPD

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