Benign Metastasizing Pulmonary Leiomyoma with Hemoptysis.

Park, So Young; Lim, Eun Ju; Jang, Ji Sun; Kim, Chang Hwan; Jee, Hyun Keun; Cho, Sung Jin; Park, Yong Bum; Lee, Jae Young; Mo, Eun Kyung

doi:2006.60.1.92

Tuberc Respir Dis > Volume 60(1); 2006 > Article

Case Report

Tuberculosis and Respiratory Diseases 2006;60(1):92-96.
DOI: https://doi.org/10.4046/trd.2006.60.1.92 Published online January 1, 2006.

Benign Metastasizing Pulmonary Leiomyoma with Hemoptysis.

So Young Park, Eun Ju Lim, Ji Sun Jang, Chang Hwan Kim, Hyun Keun Jee, Sung Jin Cho, Yong Bum Park, Jae Young Lee, Eun Kyung Mo

¹Department of Internal Medicine, College of Medicine, Hallym University, Chuncheon, Korea. bfspark@medimail.co.kr
²Department of Thoracic surgery, College of Medicine, Hallym University, Chuncheon, Korea.
³Department of Anatomical Pathology, College of Medicine, Hallym University, Chuncheon, Korea.

Abstract

A benign metastasizing pulmonary leiomyoma(BMPL) is a rare disease that is usually detected years after a hysterectomy or myomectomy. Despite the benign pathological appearance, these tumors can metastasize and become clinically malignant. Recently, we experienced case of BMPL with hemoptysis. A 43-year-old woman, who had undergone a hysterectomy due to uterine leiomyoma 8 years ago, visited our department complaining of intermittent hemoptysis. A chest CT showed bilateral multiple nodular lesions. Video-associated thoracoscopy was performed. The resected small nodular lesion revealed the proliferation of spindle cells without mitosis or nuclear atypism. The lesions tested positive to the smooth muscle marker (actin) by immunohistochemical staining. Therefore, the multiple nodules were considered as benign metastasizing pulmonary leiomyoma from a uterine leiomyoma. GnRH analogue therapy was initiated. A chest CT showed that the size and number of pulmonary lesions did not change after 3 months, and the patient was symptom free.

Key Words: Benign metastasizing pulmonary leiomyoma, Uterine leiomyoma, GnRH analogue