Tuberc Respir Dis > Volume 59(6); 2005 > Article
Tuberculosis and Respiratory Diseases 2005;59(6):600-605.
DOI:    Published online December 1, 2005.
Risk Factors for Primary Multidrug Resistant Tuberculosis.
Jinhong Min, Keeho Park, Suhee Whang, Jinhee Kim
1National Masan Hospital, Masan, Korea.
2Korea Center for Disease Control and Prevention, Seoul, Republic of Korea.
Primary multidrug-resistant tuberculosis is defined as Mycobacterium tuberculosis isolates that are resistant to at least isoniazid and rifampin in never-been-treated tuberculosis patients, and this malady is caused by the transmission of a resistant strain from one patient, who is infected with a resistant Mycobacterium tuberculosis strain, to another patient. The prevalence of primary multidrug-resistant tuberculosis could be a good indicator of the performance of tuberculosis control programs in recent years. We conducted a case-control study to identify the risk factors for primary multidrug-resistant tuberculosis. METHODS: From January 1, 2001 to, June 30, 2003, by conducting prospective laboratory-based surveillance, we identified 29 hospitalized patients with P-MDRTB and these patients constituted a case group in this study. The controls were represented by all the patients with culture-confirmed drug susceptible tuberculosis who were admitted to National Masan Hospital during the same study period. The odds ratios for the patients with primary multidrug-resistant tuberculosis, as compared with those of the patients with drug susceptible tuberculosis, were calculated for each categorical variable with 95% confidence intervals. RESULTS: Multivariate logistic regression showed that the presence of diabetes mellitus (odds ratio 2.68; 95% confidence interval, 1.05-6.86) was independently associated with having primary multidrug-resistant tuberculosis. CONCLUSION: This study has shown that diabetes mellitus might be one of the risk factors for primary multidrug-resistant tuberculosis.
Key Words: Drug resistance, Mycobacterium tuberculosis, Risk factor

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