| Progressive Lung Involvement during Steroid Therapy in Idiopathic Hypereosinophilic Syndrome. |
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Ji Young Park, Ju Young Choi, Jung Ji Min, Yun Su Sim, Gun Woo Pyun, Youn Ju Na, Min Jung Kang, In Sook Kang, Si Nae Lee, Yookyung Kim, Jee Hyong Jeong, Jin Hwa Lee, Eun Mee Cheon, Jung Hyun Chang |
1Department of Internal Medicine College of Medicine, Ewha Womans University, Seoul, Korea. hs1017@ewha.ac.kr
2Department of Pathology College of Medicine, Ewha Womans University, Seoul, Korea.
3Department of Diagnostic Radiology of Medicine College of Medicine, Ewha Womans University, Seoul, Korea.
4Department of Neurology College of Medicine, Ewha Womans University, Seoul, Korea. |
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| Abstract |
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Hypereosinophilic syndrome (HES) is characterized by a sustained eosinophilia of 1,500/mm3 or more in the absence of any known causes or the signs and symptoms of organ involvement. We report a 64-year-old man with HES initially presenting with involvement of the liver and bone marrow. Despite controlling the eosinophilia by corticosteroid, he developed a cerebral infarction and later progressive interstitial pneumonia. Brain angiography revealed a severe stenosis of the proximal right internal carotid artery (ICA) and a complete obstruction of the intracranial ICA. An open lung biopsy revealed fibrosis and lymphoplasma cell infiltration without eosinophils, which were consistent with nonspecific interstitial pneumonia. |
| Key Words:
Idiopathic hypereosinphilic syndrome |
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