A Case of Drug Induced Interstitial Pneumonitis by Gemcitabine.

Lee, Sung Soon; Ham, Cho Rom; Chin, Jae Yong; Lee, Hye Ran; Kim, Su Young; Kim, Mi Young; Lee, Hyun Kyung; Lee, Hyuk Pyo; Yum, Ho Kee; Choi, Soo Jeon

doi:2004.56.3.315

Tuberc Respir Dis > Volume 56(3); 2004 > Article

Case Report

Tuberculosis and Respiratory Diseases 2004;56(3):315-320.
DOI: https://doi.org/10.4046/trd.2004.56.3.315 Published online March 1, 2004.

A Case of Drug Induced Interstitial Pneumonitis by Gemcitabine.

Sung Soon Lee, Cho Rom Ham, Jae Yong Chin, Hye Ran Lee, Su Young Kim, Mi Young Kim, Hyun Kyung Lee, Hyuk Pyo Lee, Ho Kee Yum, Soo Jeon Choi

¹Department of Internal Medicine, Inje University, Medical School, Korea.
²Department of Radiology, Inje University, Medical School, Korea.

Abstract

Gemcitabine is an effective newly developed chemotherapeutic agent, which is increasingly being used to treat non-small cell lung, ovarian and breast cancers. Pulmonary toxicity is usually self-limiting mild dyspnea, bronchospasm, but severe pulmonary toxicity is rarely reported. Herein, we report drug induced interstitial lung disease associated with gemcitabine treatment. High resolution computerized tomogram (HRCT) showed an increased ground glass opacity and thickened septal lines. The patient showed a rapid good response with prednisolone treatment.

Key Words: Gemcitabine, Pulmonary infiltrates, Corticosteroid therapy, Capillary leak syndrome