Tuberc Respir Dis > Volume 52(5); 2002 > Article
Tuberculosis and Respiratory Diseases 2002;52(5):463-474.
DOI:    Published online May 1, 2002.
The Effect of Glutathione on High Dose Cisplatin-Induced Cellular Toxicity in Non-small Cell Lung Cancer Cell Lines.
Seoung Il Lee, Gwi Beom Boo, Dai Yong Jang, Ki Young Chung, Jeoung Gyun Seo, Byeong Lai Lee, Jong Hoon Chung
1Department of Internal Medicine, College of Medicine, Chosun University, Kwangju, Korea.
2Department of Biochemistry, College of Medicine, Chosun University, Kwangju, Korea.
This study was designed to examine how glutathione, one of the nucleophilic sulfur compounds, effects the cisplatin cellular toxicity in the non-small cell lung cancer cell lines and normal lung epithel ial cell line. METHODS: Three cultured cell lines, the lung adenocarcinoma cell(NCL-H23), the lung squamous carcinoma cell (SK-MES-1) and the normal lung epithelial cell(L-132) line were exposed to various concentrations of cisplation with or without glutathione. The relative viability was estimated as a means of measuring the cisplatin cellular toxicity using the MTT method. RESULTS: In NCL-23, the response to cisplatin was sensitive but glutathione markedly increased the relative survival of the tumor cells by removing the antitumor effect of cisplatin. In both SK-MES-1 and L-132, the responses to cisplatin were less sensitive, and the chemoprotective effect of glutathione compared to an equal cisplatin dose was signigicantly higher in L-132 than in SK-MES-1(p<0.05). CONCLUSION: The protective effects of glutathione on cisplatin-induced cellular toxicity is more signigicant in normal lung epithelial cells than in squamous carcinoma cells.
Key Words: Glutathione, High-dose cisplatin, Non-small cell lung cancer cell lines, Cellular toxicity

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