A Cse of Severe Bleomycin-Induved Pneumonitis at Non-Hodgkin's Lymphoma.

Han, Dong Ha; Min, Young Joo; Yoon, Je Hyun; Park, Jong Ho; Ahn, Jong Joon; Lee, Ki Man; Park, Jae Hoo

doi:2002.52.3.260

Tuberc Respir Dis > Volume 52(3); 2002 > Article

Case Report

Tuberculosis and Respiratory Diseases 2002;52(3):260-264.
DOI: https://doi.org/10.4046/trd.2002.52.3.260 Published online March 1, 2002.

A Cse of Severe Bleomycin-Induved Pneumonitis at Non-Hodgkin's Lymphoma.

Dong Ha Han, Young Joo Min, Je Hyun Yoon, Jong Ho Park, Jong Joon Ahn, Ki Man Lee, Jae Hoo Park

Department of Internal Medicine, Ulsan University Hospital University of Ulsan College of Medicine, Ulsan, Korea. yjmin@uuh.ulsan.kr

Abstract

Bleomycin-induced pulmonary toxitity usually occurs in the elderly patients (graeatee than 70 years old), patients with a cumulative dose above 400 units, previous chest radiotherapy, oxygen therapy, and reanal failure. H owever, there are some reports of severe pneumonitis in that developed after dministering low bleomycin doses (less than 100 units). In sever bleomycin-induced pneumonitis in non-Hodgkin's lymphoma patients, the response to corticosteroid is poor and the mortality rate is very high, approximately 83%. Therefore, clinicians should have a low threshold for investigating and treating bleomycin-induced pneumonitis. Here, we report a case of severe bleomycin-induced pneumonitis as a complication of a non-Hodgkin's lymphoma treatment.

Key Words: Non-Hodgkin's lymphoma, Bleomycin, Pulmonary toxicty