Pharmacokinetics of ofloxacin in Patients with Multidrug-Resistant Tuberculosis. |
Seung Kyu Park, Young Ran Yoon, Woo Chul Lee, Hyung Min Jun, Ji Hong Shon, Kyoung Ah Kim, Ji Young Park, Jae Gook Shin |
1Department of Chest Surgery, National Masan Tuberculosis Hospital, Korea. 2Department of Pharmacology, Inje University College of Medicine and Clinical Phamacology Center, Pusan Paik Hospital, Masan, Pusan, Korea. phyoonyr@ijnc.inje.ac.kr |
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Abstract |
BACKGROUND There are few studies that have reported on the pharmacokinetic(PK) disposition of fluoroquinolones in patients with multi-drug resistant tuberculosis(MDR-Tb), even though fluoroquinolones are frequentl y co-prescribed to those patients. In this study, the PK disposition of ofloxacin, a fluoroquinolone, was evaluated in patients with MDR-Tb. METHODS: Twenty patients with MDR-Tb were given 2nd line Tb drugs including ofloxacin (300mg twice a day), prothionamide, cycloserine, para-aminosalicylic acid, kanamycin, and streptomycin. The patients were grouped according to their body mass index(BMI) as an index of emaciation (group A: 18.5
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Key Words:
MDR-Tb, Ofloxacin, Pharmacokinetics, BMI |
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