The Changes of Serologic Markers in Pneumoconiosis of Coal Workers.

Yoo, Kwang Ha; Yun, Ho Sang; Lee, Sang Yeup; Jin, Choon Jo; Ahn, Cheol Min; Kim, Hyung Joong

doi:2001.50.5.615

Tuberc Respir Dis > Volume 50(5); 2001 > Article

Original Article

Tuberculosis and Respiratory Diseases 2001;50(5):615-623.
DOI: https://doi.org/10.4046/trd.2001.50.5.615 Published online May 1, 2001.

The Changes of Serologic Markers in Pneumoconiosis of Coal Workers.

Kwang Ha Yoo, Ho Sang Yun, Sang Yeup Lee, Choon Jo Jin, Cheol Min Ahn, Hyung Joong Kim

Abstract

BACKGROUND
Pneumoconiosis is a parenchymal lung disease that results from the accumulation of coal dust in the lungs and the consequent tissue reaction. To evaluate the role of various personal factors in pneumoconosis and the significance of some serologic markers for assessing the disease activity related to pneumoconiosis, the Rheumatoid Factor(RF), α1-AT, C-Reactive Protein(CRT), ceruloplasmin and fibrinogen levels were measured. METHOD: All the patients were males, 45-76 years old, and the mean duration of coal dust exposure was 23.2 years. 51 patients were classified as having Simple Pneumoconiosis (SP), 59 had Progressive Massive Fibrosis (PMF). Fifty eight men with ages ranging from 26-70 years wer used as normal controls. The serum RF and CRT were titrated using an Autochemistry analyzer (HITACHI 7150 : Japan) and the α1-AT and ceruloplasmin levels were measured using a Nephelometer (Behring Nephelometer : Germany) and the fibrinogen levels were estimated by using and Autoanalyzer for hematologic coagulation. RESULT: There was a higher RF level in the SP, and PMF groups than in the control groups but there was no statistical difference. The CRP, α1-AT, and ceruloplasmin levels were also higher in the SP, and PMF groups. However, the fibrinogen concentration was within the normal ranges in both the SP and PMF groups. CONCLUSION: The CWP (Ed note : Define CWP) patients had significantly higher CRP, α1-AT, and ceruloplasmin levels compared to the control group. It is believed that these serologic changes could be used as a marker of the disease activity.

Key Words: Pneumoconiosis, Rheumatoid factor, C-reactive protein, Alpha-1-antitrypsin, Ceruloplasmin