A Case of carbamazepine induced bronchiolitis obliterans organizing pneumonia.

Ok, Kyung Seon; Park, Bong Keon; Kim, Hee Suk; Lee, Hye Kyung; Jin, Seong Lim; Jin, Jae Yong; Lee, Hyuk Pyo; Kim, Joo In; Choi, Soo Jeon; Yum, Ho Kee

doi:2000.48.5.794

Tuberc Respir Dis > Volume 48(5); 2000 > Article

Case Report

Tuberculosis and Respiratory Diseases 2000;48(5):794-801.
DOI: https://doi.org/10.4046/trd.2000.48.5.794 Published online May 1, 2000.

A Case of carbamazepine induced bronchiolitis obliterans organizing pneumonia.

Kyung Seon Ok, Bong Keon Park, Hee Suk Kim, Hye Kyung Lee, Seong Lim Jin, Jae Yong Jin, Hyuk Pyo Lee, Joo In Kim, Soo Jeon Choi, Ho Kee Yum

Abstract

BOOP(Bronchiolitis Obliterans Organizing Pneumonia) is an inflammatory reaction that follows damage to the bronchiolar epithelium of the small conducting airways. BOOP is characterized by the pathologic finding of excessive proliferation of granulation tissue within the respiratory bronchioles, alveolar duct and spaces, accompanied by organizing pneumonia. BOOP may result from diverse causes such as toxic fumes, connective tissue disorders, infections, organ transplantation and drugs or appear idiopathically. Drug induced BOOP has been described in association with acebutolol, amiodarone, cephalosporin, bleomycine, tryptophan, gold salts, barbiturates, sulfasalazine, and carbamazepine. Carbamazepine is an iminostilbene derivative that is used as both and anticonvulasnt and pain reliever for pains associated with trigeminal neuralgia. It is structually related to the tricyclic antidepressants. To our knowledge, there have been no previously reported case that has described development of BOOP during carbamazepine treatment in Korea, and only two cases have been reported in the world. We report a case of carbamazepine-induce BOOP with a brief review of literature.

Key Words: BOOP, Carbamazepine, Drug induced BOOP