Tuberc Respir Dis > Volume 48(3); 2000 > Article
Tuberculosis and Respiratory Diseases 2000;48(3):377-382.
DOI:    Published online March 1, 2000.
A case of Idiopathic CD4+ T-Lymphocytopenia with disseminated Mycobacterium kansasii infection and Pulmonary alveolar proteinosis.
So Yeon Park, Jae Hyung Park, Yang Jin Jegal, Ji Hyun Lee, Chae Man Lim, Sang Do Lee, Youn Suck Koh, Woo Sung Kim, Dong Soon Kim, Won Dong Kim, Tae Sun Shim
Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Idiopathic CD4+ T-lymphocytopenia is defined as a depletion of CD4+ lymphocytes below 300/mm 3 in the absence of HIV infection or other known causes of immunodeficiency. Many infectious diseases have been reported to be associated with idiopathic CD4+ T-lymphocytopenia, and there have also been a few cases of mycobacterial infection in idiopathic CD4+ T-lymphocytopenia. Until now, it has been unclear as to whether CD4+ T-lymphocytopenia is a predisposing factor for or a consequence of the mycobacterial infection. Pulmonary alveolar proteinosis is an uncommon disease characterized by the intraalveolar deposition of amorphous granular material that stains positive with PAS, and its association with mycobacterial infection has rarely been reported. Recently, we experienced a previously healthy young man who had been diagnosed as idiopathic CD4+ T-lymphocytopenia with disseminated mycobacterium kansasii infection and pulmonary alveolar proteinosis, and report this case.
Key Words: Idiopathic CD4+ T-lymphocytopenia, Mycobacterium kansasii infection, Pulmonary alveolar proteinosis

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