Tuberc Respir Dis > Volume 48(1); 2000 > Article
Tuberculosis and Respiratory Diseases 2000;48(1):67-71.
DOI:    Published online January 1, 2000.
A Case of Pulmonary Hypertension Associated with Portal Hypertension.
Byung Min Jun, Young Rok Shin, Eun Kyung Kim, Hyun Young Kim, Sang Bum Hong, Tae Sun Shim, Chae Man Lim, Youn Suck Koh, Woo Sung Kim, Dong Soon Kim, Won Dong Kim, Sang Do Lee
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Since its first description in 1951 by Mantz and Craig, pulmonary hypertension associated with portal hypertension has been observed more frequently. In a recent prospective study Hadengue et al. reported 2% incidence of pulmonary hypertension in patients with portal hypertension. Thus this simultaneous occurrence can no longer be considered to be coincidental. The etiology remains unclear. It is most likely that vasoactive substances (,)normally metabolized by the liver(,) may gain have gained access to the pulmonary circulation through portosystemic collaterals in portal hypertension. In genetically susceptible individuals, these substances could lead to pulmonary hypertension by inducing vasoconstriction or direct toxic damage to the wall of the small pulmonary arteries. A recent case of pulmonary hypertension in a 49-year-old woman with portal hypertension due to liver cirrhosis is reported as well as a review of the literature.
Key Words: Pulmonary hypertension, Portal hypertension, Liver cirrhosis

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