Tuberc Respir Dis > Volume 47(6); 1999 > Article
Tuberculosis and Respiratory Diseases 1999;47(6):768-774.
DOI:    Published online December 1, 1999.
Interaction of Rifampin and Warfarin.
Yeon Mok Oh
Department of Internal Medicine, Boochun Sejong Hospital, Boochun, Korea.
It is well known that rifampin decreases the hypoprothrombinemic effect of warfarin by induction of cytochrome p-450 enzyme in healthy volunteer. However, in patients the dosage schedule o f warfarin during rifampin therapy is not established. Therefore, patients taking both rifampin and warfarin were reviewed to find out the adequate dosage schedule of warfafin in addition to side effects by interaction of two drugs. METHOD: Patients taking both rifampin and warfarin were retrieved from patients who were admitted due to heart disease and tuberculosis at Boochun Sejong Hospital from January of 1995 to August of 1999. To decide the adequate dosage of warfarin, the dosage of warfarin before, during, and after rifampin was evaluated in patients who kept adequate hypoprothrombinemic effect of warfarin during rifampin. To decide the adequate dosage schedule of warfarin, the time interval from the beginning of rifampin to normalization of prothrombin time(INR
Key Words: rifampin, warfarin, interaction
METRICS Graph View
  • 0 Crossref
  •   Scopus
  • 1,015 View
  • 13 Download
Related articles

Control of Breathing and Mechanics1981 June;28(2)

Article category

Browse all articles >


Browse all articles >

Editorial Office
101-605, 58, Banpo-daero, Seocho-gu (Seocho-dong, Seocho Art-Xi), Seoul 06652, Korea
Tel: +82-2-575-3825, +82-2-576-5347    Fax: +82-2-572-6683    E-mail:                

Copyright © 2024 by The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.

Developed in M2PI

Close layer
prev next