Tuberc Respir Dis > Volume 47(5); 1999 > Article
Tuberculosis and Respiratory Diseases 1999;47(5):691-696.
DOI: https://doi.org/10.4046/trd.1999.47.5.691    Published online November 1, 1999.
A Case of Pulmonary Epithelioid Hemangioendothelioma.
Kwan Yeung Kim, Chang Ho Kim, Ji Wung Sohn, Seung Ick Cha, Sang Chul Chae, Jae Yong Park, Tae Hoon Jung, Tae In Park, Keun Yeung Kwon
1Department of Internal Medicine, College of Medicine, Kyungpook National University, Korea.
2Department of Pathology, College of Medicine, Kyungpook National University, Korea.
3Respiratory Center, Kyungpook National University Hospital, Korea.
4Department of Pathology, College of Medicine, Kyemyung University, Taegu, Korea.
Abstract
Epithelioid hemangioendothelioma (EH) is a rate pulmonary vascular malignancy. Clinically, EH has been considered as an indolent, generally non-aggressive tumor. We report a case of EH which was confirmed by open lung biopsy. A 34-year-old woman was admitted for further evaluation of multiple small (less than 2cm in size) nodules, incidentally detected on screening chest radiograph. The chest CT showed multiple, relatively well-marginated, variable sized nodules at both whole lung. Transbronchial lung biopsy and transthoracic needle aspiration were nondiagnostic and open lung biopsy was performed from right middle lobe of lung. On light-microscopic examination, the nodules were composed of a poorly cellular hyaline core and a more cellular peripheral zone which extended into air space in a micropolypoid fashion and obliterated blood vessels. The tumor cells at the peripheral zone had intracytoplasmic vacuoles which suggested primitive, vascular differentiation. Immuno-histochemical study revealed the cellular area which gave positive reaction to factor VIII-related antigen. She received no specific therapy after open lung biopsy and chest X-ray films had showed no change for about two years.
Key Words: Epithelioid hemangioendothelioma, Lung


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