| Urinary 5-hydroxyindoleacetic acid (5-HIAA) excretion before and during cisplatin chemotherapy in patients with intrathoracic malignancy. |
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Dong Gyoo Yang, Yoon Soo Chang, Young Sam Kim, Jun Gu Lee, Kang Hyun Ahn, Jae Min Park, Se Kyu Kim, Hyun Cheol Chung, Joon Chang, Chul Min Ahn, Sung Kyu Kim, Won Young Lee |
1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
2Institute of Chest Diseases, Yonsei University College of Medicine, Seoul, Korea. |
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| Abstract |
BACKGROUND
Nausea and vomiting associated with chemotherapy are common side effects which remain difficult to control. Acute phase nausea and vomiting (0-24 hours after induction of chemotherapy) parallels plasma serotonin release, which explains the effectiveness of 5-HT3 receptor antagonists. Serotonin released from gastrointestinal enterochromaffin cells may mediate chemotherapy-induced emesis. In this study, we analyzed urinary excretion of 5-HIAA, the main metabolite of serotonin. METHODS: Eight men and four women were studied in their cisplatin chemotherapy cycle. Urinary 5-hydroxyindoleacetic aicd (HIAA) levels were determined before and during a 24-hour period under ondansetron prophylaxis. RESULTS: Urinary 5-HIAA excretion for a 24-hour period was increased in all patients after induction of cisplatin (P=0.002). CONCLUSION: Cisplatin chemotherapy is associated with serotonin release in the acute phase. Our finding provides evidence for a relationship between emesis and serotonin following cisplatin chemotherapy. |
| Key Words:
Nausea and vomiting, Serotonin, Urinary 5-HIAA, Cisplatin chemotherapy |
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