Risk factors of primary lung cancer and spirometry |
Yang Keun Rhee, Keum Man Hwang, Yong Chul Lee |
Department of Internal Medicine, School of Medicine, Chonbuk National University, Chonju, Korea |
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Abstract |
Background Lung cancer and chronic obstructive lung disease often coexist in the same person who are elderly and cigarette smoking. There are several reports that the presence of chronic obstructive pulmonary disease constitutes an independent risk factor for the development of lung cancer. Moreover, the association between mucus hypersecretion and lung cancer has been reported.
Methods In 72 cases with primary lung cancer which were confirmed histopathologically at Chonbuk University Hospital from August 1986 to July 1991, We evaluated the relationship between spirometry and lung cancer characteristics.
Results Six cases (8 .3%) showed normal lung function, 16(22 . 2%) cases showed pure restrictive lung disease, 46(63.9%) cases showed moderated obstructive lung disease and 4(5.6%) cases showed severe obstructive lung disease. FEV1(%) was lower in central type than in peripheral type. lower in advanced non-small cell cancer and lower in subjects with phlegm. FEV1/ FVC (%) was higher in small cell cancer than in squamous cell cancer and higher in patients without previous pulmonary disease than with previous pulmonary disease. But there was no statistically significant difference in lung function according to histologic types and smoking history_ Lung cancers with FEV1/ FVC less than 75% consisted of 35 cases of squamous cell cancer, 7 of small cell cancer (1 4%), 5 of adenocarcinoma (10%), 2 of large-cell carcinoma and 1 of unclassified carcinoma. Squamous cell carcinoma occurred more in patients with FEV1/ FVC < 75% than with FEV1/ FVC ≥ 75% (p < 0.05)
Conclusion It was suggest that low FEV1/ FVC, as reflection of obstructive lung disease, may be at greater risk for squamous cell carcinoma in cigarette smoker |
Key Words:
Lung cancer, Spirometry |
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