Tuberc Respir Dis > Volume 40(2); 1993 > Article
Tuberculosis and Respiratory Diseases 1993;40(2):185-191.
DOI:    Published online April 1, 1993.
Expression of intercelluar adhesion molecule-1 in human idiopathic pulmonary fibrosis.
Sung Soo Park1, Dong Ho Shin1, Tae Wha Kim1, Dong Hoo Lee1, Jung Hee Lee1, Jung Dal Lee2
1Department of Internal Medicine, Hanyang University Hospital, Seoul, Korea
2Department of Pathology, Hanyang University Hospital, Seoul, Korea
intercellular adhesion molecule-l (ICAM-ll is a 90 kD surface glycoprotein, associated with αLβ2 and αMβ2 subunit of integrins, that serve as cell-cell and cell -substratum adhesion molecules and help regulate cellular morphology, differentiation, and proliferation. The adhesion molecules likely play important roles in maintaining the normal structure and function of the lung ICAM-l system among many cell adhesion molecules is importantly issuing in the pathogenesis of idiopathic pulmonary fibrosis.
By using IgG1 monoclonal antibody for ICAM-l, we investigated immunohistochemically the expression of ICAM-l in the formalin-fixed, paraffin-embedded tissue sections of the 3 normal cases and 6 pieces of tissues taken 3 cases with idiopathic pulmonary fibrosis.
ln the 3 normal cases, the expressions of lCAM-l were not discernible. Up-regulation of the ICAM -l expression was showed in the interstitia l fibroblast cells of a lveolar septa in 5 pieces and proliferated alveolar pneumocytes in 1 piece among 6 pieces of tissues taken 3 cases with idiopathic pulmonary fibrosis.
lt was concluded from these findings that up-regulation of the ICAM-l expression may be related to pathogenesis of idiopathic pulmonary fibrosis.
Key Words: Expression, lntercellular adhesion molecule-l, Idiopathic pulmonary fibrosis

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