| The change of squamous cell cancer antigen(SCC Ag) level as a tumor marker in squamous cell lung cancer. |
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Young Jun Kim, In Won Park, Byung Whui Choi, Sung Ho Hue |
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Department of Internal Medicine, College of Medicine, Chung Ang University, Seoul, Korea |
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| Abstract |
Background
It has beeen known that SCC antigen was used in diagnosis of uterine cervical cancer and also known to be higher in squamous cell lung cancer. There has been no report about SCC antigen in squamous cell lung cancer in Korea. This study was designed to evaluate the usefulness of SCC antigen as a diagnostic tool and index for follow up after treatment.
Methods
The serum level of SCC antigen was measured in 12 cases with squamous cell lung carcinoma, 9 patients with other types of lung cancer, 7 patients with benign lung disease and 7 normal subjects by radioimmunoassay with Abott SCC Riabeap radioimmunoassay kit. We also measured SCC antigen after treatment in 6 patients who had received chemotherapy or surgery.
Results
1) The level of SCC antigen (mean ± 1 SD) was 2.27 ± 1. 53, 0.67 ± 0.38, 0.62 ± 0.53, 0.53 ± 0.36 ng/ ml respectively.
2) The SCC antigen activity in squamous cell lung carcinoma according to stage were as gollows I; 2.07 ± 1. 56, IIIa; 5.04 ± 0.53 IIIa; 1. 94 ± 0.7 IV; 1. 07 ± 0 .64 (ng/ ml). 3) In squamous celllung cancer, 5 of 12 (42%) cases was shown more than 2.0 ng/ ml SCC antigen.
(sensitivity; 42% ), but there was no case in any other type of lung cancer, benign lung disease, and in control groups (specificity; 100%). 4) The serum SCC antigen level after treatment was significantly decreased in patients with partial or complete remission (p<0.01)
Conclusions
It was suggested that SCC antigen might be used as a useful tumor marker for the response of treatment and assessment of prognosis in squamous cell lung cancer, but further study should be performed for the clinical use of SCC antigen |
| Key Words:
Squamous cell lung cancer, Squamous cell cancer antigen |
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