Effects of corticosteroid on the paraquat induced lung injury.

Chang, Keun; Kim, An Myung; Kang, Jeong Seong; Jung, Byung Hak; Jeong, Eun Taik; Moon, Hyung Bae

doi:1992.39.4.325

Tuberc Respir Dis > Volume 39(4); 1992 > Article

Original Article

Tuberculosis and Respiratory Diseases 1992;39(4):325-333.
DOI: https://doi.org/10.4046/trd.1992.39.4.325 Published online August 1, 1992.

Effects of corticosteroid on the paraquat induced lung injury.

Keun Chang¹, An Myung Kim¹, Jeong Seong Kang¹, Byung Hak Jung¹, Eun Taik Jeong¹, Hyung Bae Moon²

¹Department of Intemal Medicine, Wonkwaηg University College of Medicine, Iri, Korea
²Department of Pathology, Wonkwaηg University College of Medicine, lri, Korea

Abstract

Background
and Methods: To study the effects of corticosteroid (CS) on the parquat (PQ) induced lung injury, serial cellular anal yses of bronchoalveolar lavage (BAL) fluid were done with simultaneous histopathologic examination after intraperitoneal injection of PQ on the rats. The sacrificed animals were divided into three groups; control group, PQ group received intraperitoneal injection of 20 mg/ kg of PQ, and CS group received daily injection of Methylprednisolone sodium succinate (20 mg/ kg) in addition to PQ.
Results
1) Cellular analyses of BAL fluid: The total cell count in the BAL fluid were increased gradually from 6 hours after PQ administration (p < 0.05), and was decreased at 3 days after (p < 0.05). These changes were mainly due to the effects of PQ on the neutrophil influx (p < 0.05). But, the number of macrophage and the percentage of lymphocyte in total cells showed little changes. The CS administration showed the suppression of neutrophil influx in the BAL fluid (p < 0 .05), but could not show any significant effect on the number of macrophage and lymphocyte. 2) Histopathologic examination: In the PQ group, inflammatory changes especially with prominent neutrophil infiltration were gradually progressed over time. Those changes were found in both alveolar space and interstitium with resultant alveolar structural changes, but subsided from 3 days after. CS suppressed inflammatory changes in the alvolar space and interstitium, especially with decreased infiltration of neutrophil.
Conclusion
CS suppressed neutrophil infiltration in the acute lung injury induced by PQ, those findings were ascertained by serial cellular analyses of BAL fluid and histopathologic examination.

Key Words: Paraquat, Acute Lung Injury, Corticosteroid

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