Tuberc Respir Dis > Volume 39(4); 1992 > Article
Tuberculosis and Respiratory Diseases 1992;39(4):325-333.
DOI:    Published online August 1, 1992.
Effects of corticosteroid on the paraquat induced lung injury.
Keun Chang1, An Myung Kim1, Jeong Seong Kang1, Byung Hak Jung1, Eun Taik Jeong1, Hyung Bae Moon2
1Department of Intemal Medicine, Wonkwaηg University College of Medicine, Iri, Korea
2Department of Pathology, Wonkwaηg University College of Medicine, lri, Korea
and Methods: To study the effects of corticosteroid (CS) on the parquat (PQ) induced lung injury, serial cellular anal yses of bronchoalveolar lavage (BAL) fluid were done with simultaneous histopathologic examination after intraperitoneal injection of PQ on the rats. The sacrificed animals were divided into three groups; control group, PQ group received intraperitoneal injection of 20 mg/ kg of PQ, and CS group received daily injection of Methylprednisolone sodium succinate (20 mg/ kg) in addition to PQ.
1) Cellular analyses of BAL fluid: The total cell count in the BAL fluid were increased gradually from 6 hours after PQ administration (p < 0.05), and was decreased at 3 days after (p < 0.05). These changes were mainly due to the effects of PQ on the neutrophil influx (p < 0.05). But, the number of macrophage and the percentage of lymphocyte in total cells showed little changes. The CS administration showed the suppression of neutrophil influx in the BAL fluid (p < 0 .05), but could not show any significant effect on the number of macrophage and lymphocyte. 2) Histopathologic examination: In the PQ group, inflammatory changes especially with prominent neutrophil infiltration were gradually progressed over time. Those changes were found in both alveolar space and interstitium with resultant alveolar structural changes, but subsided from 3 days after. CS suppressed inflammatory changes in the alvolar space and interstitium, especially with decreased infiltration of neutrophil.
CS suppressed neutrophil infiltration in the acute lung injury induced by PQ, those findings were ascertained by serial cellular analyses of BAL fluid and histopathologic examination.
Key Words: Paraquat, Acute Lung Injury, Corticosteroid

Article category

Browse all articles >


Browse all articles >

Editorial Office
101-605, 58, Banpo-daero, Seocho-gu (Seocho-dong, Seocho Art-Xi), Seoul 06652, Korea
Tel: +82-2-575-3825, +82-2-576-5347    Fax: +82-2-572-6683    E-mail:                

Copyright © 2023 by The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.

Developed in M2PI

Close layer
prev next