A review of subacute necrotizing lymphadenitis.

Jang, Chang Hoon; Kwon, Soon Seog; Kim, Young Kyoon; Kim, Kwon Hyoung; Han, Ki Don; Moon, Hwa Sik; Song, Jeong Sup; Park, Sung Hak

doi:1991.38.3.297

Tuberc Respir Dis > Volume 38(3); 1991 > Article

Original Article

Tuberculosis and Respiratory Diseases 1991;38(3):297-303.
DOI: https://doi.org/10.4046/trd.1991.38.3.297 Published online September 1, 1991.

A review of subacute necrotizing lymphadenitis.

Chang Hoon Jang, Soon Seog Kwon, Young Kyoon Kim, Kwon Hyoung Kim, Ki Don Han, Hwa Sik Moon, Jeong Sup Song, Sung Hak Park

Department of Internal Medicine, Catholic University Medical College Seoul, Korea

Abstract

Subacute necrotizing lymphadenitis is characterized by cervical lymphadenopathy in young patients and mistaken for malignant disease both clinically and histologically. Microscopically, there is a varying degree of effacement of the lymph node architecture and necrosis with an infiltrate of histiocytic cells and absence of polymorphs. We have experienced 4 cases of cervical lymphadenopathy accompanied by fever. All cases had complete recovery to conservative treatment only. The excised lymph nodes were moderately enlarged and typically showed varying degrees of necrotizing lesions, and abundant karyorrhectic debris, scattered fibrin deposits, aggregates of large mononuclear cells, and a paucity of plasma cell and neutrophils. For investigating the etiology and pathogenesis of this lesion, further clinical study and stepwise pathologic and immunologic planning would be valuable.