| The effect of radiation therapy on cellular immune response in patients with squamous cell lung carcinoma. |
|
Soo Taek Uh1, Chul Hyun Kim1, Yeon Tae Chung1, Yong Hun Kim1, Choon Sik Park1, Hi Bahl Lee1, Seung Jae Huh2 |
1Department of Internal Medicine, College of Medicine Soonchunhyang University, Seoul, Korea
2Department of Therapeutic Radiology, College of Medicine Soonchunhyang University, Seoul, Korea |
|
|
| Abstract |
|
The immune staus is known to be decreased in malignant disease and radiation therapy (RT), used
as a therapeutic tool, further decreases this-attenuated immune status. We measured the number of peripheral lymphocytes, its subsets and lymphoblast transformation for PPD, PHA, monoclonal antibodies including anti.CD3 and anti-CD2 before and after RT in 19 patients with squamous cell lung cancer to search the fine mechanism behind the RT.induced attenuation of lymphoblast transformation for mitogens and antigen.
The results were as follows;
1) The number of lymphocytes and its subsets decreased significantly after RT, but the percentages of lymphocyte subsets did not change after RT except interleukin-2 receptor positive T lymphocytes.
2) The function of lymphocytes, measured by lymphoblast transformation for PHA and PPD, decreased after RT and the compositions of PBMC used for lymphoblast transformation were not different before and after RT.
3) The mitosis of lymphocytes to anti-CD2 or anti-CD3 decreased significantly after RT. And IL-2 plus anti-CD3 increased the mitosis than that of anti-CD3 only after RT, but before RT there was no difference.
In conclusion, we suggested the fine mechanism behind the RT-induced attenuation of immune response might be the dysfunction of lymphocytes in terms of impaired synthesis of IL-2 rather than the decrease of circulating lymphocyte numbers. |
|
PDF Links
Full text via DOI
Download Citation
