| Results of Korean B.C.G. Vaccination |
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Sung Kwan Lee, Nak Chin Chang |
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Department of Preventive Medical College of Kyungpuk National University , Kyungpuk, Korea |
| 한국 B.C.G. 의 접종성적 |
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이성관, 정낙진 |
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| Abstract |
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The effect of B.C.G. depends on the number of bacilli contained in the suspension and it is very hard to expect a sufficient effect with imported B.C.G., because the potency may vary during its trans-portation due to inadequate handling and storage. Fortunately， we could now produce this B.C.G. at the National Central Laboratory since this year. The potency of B.C.G. varies between the products of different laboratories even in the same country.
Author thought that is very significant to investigate the potency of B.C.G. produced in Korea and the comparison were made between the potency of the ]apanese dried B.C.G. and Korean B.C.G.
1) Viability test shows that the Korean liquid B.C.G . , contained of living bacilli only 100, 000/ 0.1cc and after storage at 4℃ for 10 days since their production 25% of the bacilIi decreased but at Room temperature of 13℃ ~20℃ 20% of bacilli decreased. However during the period after 10 days of their production, the group stored at Room temperature showed much higher rate of decreasing than the group stored at 4 ℃.
2) Thc local lesion produced after vaccination in the group in which 0.05cc of Korean B.C.G. was injected in the both sides was slightest. There was no marked difference in the degree of local lesion between the groups in which 0.1cc of Japanese and Korean B.C.G. were injected only in one side. It was most marked in the group in which 0.1cc of Korean B.C.G. were injected in both sides.
3) Tuberculin allergy-induced after Vaccination was compared between the two groups in which 0.1cc of Korean and ]apanese B.C.G. was vaccinated in one side.
There was no marked difference within one or two months, but after 3 months the tuberculin allergy of Korean B.C.G. decreased rapidly and the pòsitive rate and mean size also decreased considerately as compared with ]ap anese B.C.G.
4) In the opsonin test, opsonin index of postvaccination increassdl markedly than that of prevaccination, but no difference in the index was noted between the different methods of vaccination.
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