Urine PAS Test in Pulmonary Tuberculosis Patiets Treated on Ambulatory Base

Lee, Hyo Keun; Hong, Jin Keun; Lee, Ki Yong; Park, Sung Ok; Min, Bum Shik; Choi, Yong Ok; Ham, Sung Sook

doi:1961.0.10.65

Tuberc Respir Dis > Issue 10; 1961 > Article

Tuberculosis and Respiratory Diseases 1961;10:65-67.
DOI: https://doi.org/10.4046/trd.1961.10.1.65 Published online December 1, 1961.

Urine PAS Test in Pulmonary Tuberculosis Patiets Treated on Ambulatory Base

Hyo Keun Lee, Jin Keun Hong, Ki Yong Lee, Sung Ok Park, Bum Shik Min, Yong Ok Choi, Sung Sook Ham

Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea

통원치료 폐결핵환자의 Urine PAS Test의 임상적 관찰

이효근, 홍진근, 이기용, 박성옥, 민범식, 최용옥, 함성숙

Abstract

Para-aminosalicylic acid(PAS ) is frequently used in conjunction with other antituberculous agents in the combined therapy of tuberculosis. Many patients do not tolerate PAS in adequate doses because of side effects or the inconvenience of ingesting may talets of relatively large size throughout the day. Furtermore, it is the general experience among physicians working with tuberculous patients that many who do not take the drug do not inform their physicians of this fact or vigorously deny their lack of adherence to a prescribed program. Five hundred and seventeen ambulatory pulmonary tuberculosis patients prescribed PAS as one of their antimicrobial drugs were subjected to a urine PAS test and were questioned by a physician at one of four clinics. The percentage of patients with negative urine PAS tests varied considerably from clinic to clinic, but average 13.7 percent. The percentage of patients with negative urine PAS tests varied considerably form clinic to clinic, but averaged 1.7 percent. The percentage of negative tests was higher among female patients than among mal, Negative rates increased in the are group from 20 to 49 and was considerably lower under 19 and above 50 years of age. Negative rates were higher in patients with less extensive disease and with negative bacteriologic findings. Negative rates were higher in patients with less education and in those no charged for their drugs. Negative rates increased also with the length of time that PAS was prescribed. After 19 months of therapy, however, this trend was reversed. Persuasion and adequate explanation of the necessity of regular chemotherapy will reduce the incidence of negative tests for urine PAS.

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