Clinical Observation on the Effect of Secondary Antituberculosis Drugs

Suh, Ki Cho

doi:1970.17.3.27

Tuberc Respir Dis > Volume 17(3); 1970 > Article

Original Article

Tuberculosis and Respiratory Diseases 1970;17(3):27-32.
DOI: https://doi.org/10.4046/trd.1970.17.3.27 Published online September 1, 1970.

Clinical Observation on the Effect of Secondary Antituberculosis Drugs

Ki Cho Suh

Department of Internal Medicine College of Medicine, Chun Nam National Univercity, Kwangju, Korea

이차항결핵제의 효과에 대한 임상적 관찰

서기초

Abstract

The author has made a study on the clinical effectiveness of secondary antituberculosis chemotherapy with various regimens of ethambutol(EB), pyrazinamide(PZA), cycloserine(CS) and ethionamide(TH) on seventy-two patients of adult pulmonary tuberculosis who were bacteriologically and clinicaIly resistant to primary antituberculous therapy. Ninty percent of patients were used on the secondary antituberculous agents for ten months or more, but ten percent of patients were ceased treatment because of toxic effects and also for failure of sputum conversion after six months therapy. The results were summarized as follows. 1) Sixty-nine percent of patients became :negative on culture for four concecutive months or more and thirty-one percent were stiIl positive at four months or more. The onset of sputum conversion began at one month after treatment in twenty-four percent of the cases, at two months in thirty-seven percent, at three months in thirty-one percent and none after five months. 2) The roentgenological improvement occured in seventy-two percent as a whole and became worse in nine percent. 3) In general, regimen-IV(INH+TH+EB) appeared to be the most effective one in the treatment of resistant tuberculosis cases against the primary drugs after one years of treatment. 4) The toxic effects of the secondary antituberculous agents were observed in sixteen percent of pyrazinamide containing group, twelve percent of the group with cycloserine and gastrointestinal troubles with ethionamide occured in thirty percent of the groups.

TOOLS

PDF Links
Full text via DOI
Download Citation
Share :

METRICS

0 Crossref
Scopus
868 View
12 Download

Related articles

On Operative Treatment of Cavernous Tuberculosis of the Lung

Clinical Observations of the Solitary Pulmonary nodules1989 December;36(4)

Clinical Study on 28 Cases of Endobronchial Tuberculosis1989 September;36(3)

Clinical Observation on Solitary Pulmonary Nodules1989 March;36(1)

Clinical Observation of Endobronchial Tuberculosis1986 June;33(2)

ABOUT

ARTICLE & TOPICS

Article category

Browse all articles >

Topics

Browse all articles >

BROWSE ARTICLES

FOR CONTRIBUTORS

Editorial Office: 101-605, 58, Banpo-daero, Seocho-gu (Seocho-dong, Seocho Art-Xi), Seoul 06652, Korea
Tel: +82-2-575-3825, +82-2-576-5347 Fax: +82-2-572-6683 E-mail: katrdsubmit@lungkorea.org