| The Clinical Effects of Treatment with Myambutol, -2, 2`(ethylenediimino) di-1-butanol dihydrochloride- |
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Chan Sae Lee |
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Visiting Prof. Intern. Med. Catholic Medical College, Seoul, Korea |
| 2,2`(ethylenediimino)-di-1-butanol dihydrochloride (Myambutol)의 임상효과 |
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이찬세 |
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| Abstract |
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Author's Summary;
1) The author reviewed the results of administration of Myambutol on 107 cases of pulmonary tuberculosis under ambulatory system. 77 cases continued the treatment for more than 6 months were subjected for further evaluation of clinical effects.
2) 67 patients were retreatment cases with long standing history of various chemotherapy including most of secondary drugs, average for 6. 5 years duration but 14 of those had no secondary drugs. Only 10 patients were initial treatment cases with less than 3 months duration of disease.
The doses of myambutol were 25-15 mg per KgBW, once daily one hour before breakfast.
For the initial treatment cases INH and SM or INH SM and PAS were combined together. For the retreatment cases only INH was combined because they had all the drugs already. Several cases who had no secondary drugs previously were given one or two secondary arugs together.
3) The overall results of myambutol treatment at 6-12 months showed that the rate of rentgenologic improvement more than moderate degree were 70% for the initial cases, 31. 34% for the retreatment casese and the rates of sputum conversion were 100% for initial, 53. 13% for retreatment cases. And one case showed definite progression of X-ray picture with persistent positive sputum. The sputum conversion occurred earlier than the improvement of X-ray picture, 28.57% to 17.86% at 3 months, but most improvements of both catagories were achieved between 4 to 8 months of the treatment, 92.86% to 82. 15% accumulately.
4) It was impossible to measure the differences of the results according to the variance of the combination regimes. However the group treated with myambutol and INH only showed the poorest results in X-ray improvement(16.42%) but the author interpreted it as a reasonable consequence, because they were the group with the logest duration of the disease and the least degree of changeability of the lesions. The sputum conversion rate was not much inferior (50%) in this group than others, because myambutol worked as a chemotherapeuticum directly toward to the pathogenic organisms.
5) As the side effects of myambutol there were 3 cases of visual disturbances(2. 8% of 107 patients), and 2 cases (1. 87%) of hypersensitivity reaction with chief complaints of nausea, fever, general bodyache, although not severe. The former developed after several months treatment and the later occurred with only one or two doses of myambutol.
Most side effects were disappeared soon after the cessation of the drug but one case of slight degree -visual disturbance persisted for more than 6 months after the withdrawal of the drug.
6) It would be an author’s opinion that myambutol could be one of the additional potent drugs in case of initial treatment of severe cases as well as resistant cases to primary drugs, but the occurence of visual disturbance as a side effect and the high cost of the drug could be the main drowbacks as other secondary drugs already we have. |
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