Effect of several anti-cancer drugs on interstitial tissue of the lungs in rats

Kim, Ki Ho; Lee, Won Young

doi:1975.22.3.105

Tuberc Respir Dis > Volume 22(3); 1975 > Article

Original Article

Tuberculosis and Respiratory Diseases 1975;22(3):105-107.
DOI: https://doi.org/10.4046/trd.1975.22.3.105 Published online September 1, 1975.

Effect of several anti-cancer drugs on interstitial tissue of the lungs in rats

Ki Ho Kim, Won Young Lee

Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea

항암제가 동물 폐실질에 미치는 영향

김기호, 이원영

Abstract

The first pulmonary interstitial fibrosis is appeared to be reported by Hamman and Rich in 1944. Then, many similar reports had been made. Smith (1963) had reported radiation pneumonitis and its consequent fibrosis of the lung. Davies (1969) made a review of drug-induced lung disease, and well summarized its mechanism. Bleomycin, Cytoxan , 5-FU and methotrexate have been studied in repeated administration up to 4th week. Author made a study on interstitial fibrosis of rats, and obtained the followings: 1) Throughout the experiment five rats died without definite causes. 2) Patho logic findings of removed lung showed no evidence of interstitial fibrosis.