The Effect of Ethambutol on Uric Acid Metabolism

Min, Wu Sung; Cho, Eui Suk; Back, Nam Jong; Jeong, Jin Wu; Park, Sung Hak; Byun, Hae Won

doi:1979.26.1.24

Tuberc Respir Dis > Volume 26(1); 1979 > Article

Original Article

Tuberculosis and Respiratory Diseases 1979;26(1):24-26.
DOI: https://doi.org/10.4046/trd.1979.26.1.24 Published online March 1, 1979.

The Effect of Ethambutol on Uric Acid Metabolism

Wu Sung Min, Eui Suk Cho, Nam Jong Back, Jin Wu Jeong, Sung Hak Park, Hae Won Byun

Department of Internal Medicine, Catholic Medical College, Seoul, Korea

Ethambutol이 뇨산대사에 미치는 영향

민우성, 조의숙, 백남종, 정진우, 박성학, 변해원

Abstract

Ethambutol has found its wide clinical acceptance as an effective agents for the treatment of Mycobacterium Tuberculosis infection in human. There were different reports that ethambutol has an effect on the uric acid metabolism by some authers. We studied the effect of ethambutol therapy in a daily dose of 8PO mg on the uric acid metabolism in 40 active tuberculosis patients (male: 14 and female 26), who had normal kidney function and no metabolic disorders. on a regular hospital low-purine diet. 1) The serm concentration of uric acid were 3.2±0.9mg/ dl before treatment and 4.1±1.3 mg/dl after ethambutol therapy for 5 days. 2) The ratio of urate clearance to creatinine clearance (C urate / C creatinine) were 0.16::t 0.09 before treatment and 0.15±0.08 after ethambutol therapy for 5 days 3) The ratio of urine urate to urine creatinine ( U urate/U creatinine) werl 0.60 ± O.l8 before treatment and 0.54 ± 0.20 after ethambutol therapy for 5 days. Our studies suggests that that ethambutol produces hyperuricemia by decreasing renal clearance of uric acid.