Natural Killer Cell Mediated Cytotoxicity in Tuberculosis Patients

Moon, Hwa Sik; Kim, Hoon Kyo; Kim, Ho Youn; Park, Sung Hak; Kim, Choon Choo; Kim, Dong Jip; Byun, Hae Won

doi:1981.28.4.151

Tuberc Respir Dis > Volume 28(4); 1981 > Article

Original Article

Tuberculosis and Respiratory Diseases 1981;28(4):151-156.
DOI: https://doi.org/10.4046/trd.1981.28.4.151 Published online December 1, 1981.

Natural Killer Cell Mediated Cytotoxicity in Tuberculosis Patients

Hwa Sik Moon, Hoon Kyo Kim, Ho Youn Kim, Sung Hak Park, Choon Choo Kim, Dong Jip Kim, Hae Won Byun

Department of Internal Medicine, Catholic Medical College, Seoul, Korea

결핵환자의 자연살해세포 매개 세포 파괴능

문화식, 김훈교, 김호연, 박성학, 김춘추, 김동집, 변해원

Abstract

The tuberculosis is one of the diseases related with cellular immune reaction. Recently natural killer cells (NK cells) are highlighted as one of the cells related to immune surveillance. In oder to observe the relationship between tuberculosis and NK cell activity, authors studied natural killer cell mediated cytotoxicity (NKMC) in adult patients with active pulmonary tuberculosis (n=44) and healthy controls (n= 11). The patients were divided into three groups according to the extent of disease, i.e., minimal (n=15), moderatly advanced (n=16) and far advanced pulmonary tuberculosis (n= 13). Standard ⁵¹Cr release assay was used for the assessment of NKMC between K562 cell line (target cells) and nonadherent peripheral blood mononuclear cells obtained from patients (effector cells). The results were as follows: 1) In healthy controls, the mean NKMC was 42 ± 7. 1% in effector/targetcell, 50: 1 and 21 ± 4.0% in 25 : 1. 2) In active pulmonary tuberculosis patiimts, the mean NKMC was 23 ± 4.7% in effector/ target cell, 50: 1 and 17 ± 3. 9% in 25 : 1. 3) The mean NKMC of active pulmonary tuberculosis patients was significantly lower than that of controls in 50 : 1 and 25 : 1. 4) There was no significant difference in the mean values of NKMC among the minimal, moderatly advanced and far advanced pulmonary tuberculosis patients in 50 : 1 and 25 : 1. Depressed NKMC in tuberculosis patients suggests that NK cell is related to the cellular immune reaction of tuberculosis. It is not clear whether depressed NKMC in tuberculosis patients is directly related to cell mediated immune reaction in tuberculosis or seguela, and further study is necessary to understand our results.

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